Investigation On Utilization Of Antibacterial Agents In A Class Three Grade-A Hospital

Objective:We investigated and analyzed antibacterial agents use in outpatients and hospitalized patients in a first class hospital, in order to comprehensively evaluate the rationality of antibacterial agents uses in non-surgery patients, the surgical operation and outpatient service patients, which can provide basis for improving the rationality of antibacterial agents uses clinically, strengthening the management of clinical use of antibiotics, enhancing the level of clinical medication and reducing health care costs.Methods:The total income of the medical service, drugs earning and antibiotics use were investigated in 2010, the proportion of drugs accounts for the hospital income and the antibiotics accounts for the drugs were calculated. The first 20 kinds of drugs were sorted according to their amounts of drug sales in 2010, and the first 20 kinds of antibiotics were sorted according to defined daily dose system (DDDs). A sample of 400 non-surgery inpatient cases,400 inpatients cases hospitalized for operation,46543 prescriptions of outpatients and 120 patients each of thyroid surgery,breast surgery, external hernia surgery in type I incision operation of the hospital in all the year of 2010 were randomly selected. The using situation of antibiotics were investigate and analyzed in the above cases accordance with the method specified in implementation of guidelines for antibacterial use in clinical practice and the management of the clinical use of antibiotics issued by Ministry of Health Office (Office of Ministry of Health issued (2009) 38). We designed correlative tabulations to analyze the information obtained by this method and data statistically. The using situation of antibiotics was appraised based on their applications.Result:The amount of antibacterial agents consumption accounted for 21.21% in all drug costs in the hospital. The use rate of antibacterial agents was 20.94% in outpatients, while the rate was 92.54% and 39.25 % respectively for inpatients of type I incision operation and without operations, following 68.00% and 33.13% in combined administration. The amount of prophylactic antibiotics without indications for patients undergoing type I incision operations was 66.67%, and 87.50% cases with the preventive use of antimicrobial agents for too long after operation as well as non-compliance.Conc lusion:The unreasonable phenomenon of the antibacterial agents used in the hospital was extensive, manifested in high-grade antibiotics used, no indication of a high proportion of combination therapy, a single higher dose, the low frequency of administration, prolonged treatment, the low rate of pathogenic examination and drug susceptibility testing. The situation was worse for the inpatients of surgical operation than the hospitalizations not performing surgical operation. The use rate of antibacterial agents and the rate of combined use are high. The drug of choice was beyond the relevant regulations. Dosage regimen was inappropriate and so on.Therefore, medical staff should continue to strengthen the rational use of antimicrobial agents knowledge training, strict implementation of hospital management system, classification of antimicrobial agents, while focusing on pathogens and antimicrobial susceptibility test checks to continuously improve the level of rational use of hospital antibiotics.