Studys On The Preparation And Quality Standards Of Jiaoai Decoction Agent

Tom prescription only found Jiaoai Zhongjing "Golden Chamber woman and pregnancy certificate rule disease chapter twenty-pulse",by the donkey-hide gelatin, leaves, to yellow, white peony root, angelica, Chuanxiong, Chinese medicine composed of licorice Qiwei,with nourishing bleeding, the effect of menstruation tocolysis,clinical often based on the original side addition and subtraction use for the treatment of dysfunctional uterine bleeding, habitual abortion, threatened abortion, incomplete abortion, postpartum uterine involution failure, luteal phase defect, irregular menstruation and other gynecological diseases.The project by "national technical requirements of Chinese drug"will be developed into a plastic soup medicine decoction Ai agent preparations, the preparation process, quality standards and the preparation of the initial stability of the aspects of the system.Molding study investigated the type and amount of flavoring agent,Determine the prescription, specification, usage and dosage and method of terminal sterilization,three batches of 10 times at the same time a small amount of test prescribed test,established a scientific and rational technology route.Preparation:reference Zhongjing Jiaoai soup usage, and prescription drugs in the physical and chemical properties of biological active ingredients, pharmacological effects and clinical applications, while traditional and modern extraction technology based on test results compared to draw the line extraction process.single factor test, herbs soaking time, sake concentrations were studied to determine the appropriate concentration of the immersion time and sake;by L9 (34) orthogonal test, plus the amount of solvent, extraction time, extraction times were investigated, and to determine the optimum extraction conditions; molten gelatin amount of water and temperature study to determine the suitability of the molten condition.Quality Standards:To ensure the quality control agents, make full use of modern technology, Tang decoction Jiaoai agent of the quality standards were studied.By thin layer chromatography (TLC) on the preparation leaves, white peony root, licorice root, Chuan Xiong, Radix Angelica flavors for TLC identification; high performance liquid chromatography (HPLC) determination of paeoniflorin in Paeonia of the active ingredient content, and methods Science test inspection. Full Tang decoction Jiaoai established quality control system agent. Preliminary stability test preparation:Reserve sample observation by agents over a period of 6 months on the stability,At 0 month,1 month,2 months,3 months,6 months preparation regularly character, identification, determination, relative density, load difference should not matter, and so on detection,the results showed that all the indexes were not significantly different, both standard and "Chinese Pharmacopoeia"2010 version of a decoction agent under the relevant provisions of good stability.