Study On Bark Of Chinese Catalpa In Ephedra, Forsythia Root And Red Adzuki Bean Decoction Of Treatise On Febrile Diseases

As society and time change,a variety of phenomena of the drugs application in classical prescriptions occur, such as changes of drug species, drug reduction, drug substitution and so on. As the research object to bark of Chinese catalpa in Ephedra,Forsythia root and Red adzuki bean Decoction, in terms of literature researches and experimental studies,this paper discusses the species confirmation, evolution and the relationship with the congener bark of catalpa bungei in Treatise on Febrile Diseases, and tries to seek ideas for clinical application of drugs in classical prescriptions.In view of the high clinical value of Ephedra, Forsythia root and Red adzuki bean Decoction in Treatise on Febrile Diseases,as well as the scant treatises and constant arguments about the species confirmation of bark of Chinese catalpa,literature research of this paper combined botany,exegesis,archeology,history and herbalism,radicated the source of bark of Chinese catalpa in Zhang Zhongjing's period and the relationship with the congener bark of catalpa bungei,Thereby,we believe that catalpa and catalpa bungei are confusable in the Eastern Han Dynasty,in addition,bark of Chinese catalpa used by Zhang Zhongjing could be bark of catalpa bungei. Basically disappeared in some places till the Jin and Tang Dynasties, thence, capillary artemisia and white mulberry root-bark replaced bark of Chinese catalpa for clinic. Whereas, ancient physicians argued a lot on this phenomenon.In order to further confirm the plant variety of bark of Chinese catalpa in Treatise on Febrile Diseases,this article also discussed in view of integral experiment. We respectively used bark of Chinese catalpa, bark of catalpa bungei and white mulberry root-bark to replace bark of Chinese catalpa in Ephedra, Forsythia root and Red adzuki bean Decoction and observed the effects of liver injury model under different mechanisms intervened by the three prescriptions.Effect results in chemical liver injury caused by CCL4 of the three prescriptions indicates that each dose-group of bark of catalpa bungei evidently reduced the serum ALT,AST and the bilirubin of mice,middle and large dose groups of White Mulberry Root-bark also had remarkable function,by contrast, three dose groups of bark of Chinese catalpa did not have much effect.Effect results in immunological liver injury in mouse cell system caused by BCG+LPS of the three prescriptions indicates that large and middle dose-group of bark of catalpa bungei evidently reduced the serum ALT,AST and Blio of mice,large dose-group of white mulberry root-bark also had remarkable function,three dose groups of bark of Chinese catalpa did not have much effect yet. Such diversity in different liver injury model may relate to different mechanism of action of Ephedra, Forsythia root and Red adzuki bean Decoctions formed by various kinds of succedaneum.This is to be proven by further researches.Modern research results as above offer powerful evidence to confirm that bark of Chinese catalpa in Treatise on Febrile Diseases is bark of catalpa bungei. It also testifies that bark of Chinese catalpa replaced by white mulberry root-bark at present is reasonable but not the best choice. Whereas the research limitations of the whole compound,this paper puts forward the future research directions centers on if there are differences among the single drugs.