| Objective: Of triple negative breast cancer pathology, molecular biology of indications (CK5 / 6) in traditional Chinese medicine syndromes in the expression and the differences between the syndromes for the triple negative type of breast cancer to provide TCM objective indicators.Research method: Collected from July 2006 to December 2010 Affiliated Hospital of Shandong University of Traditional Chinese Medicine Breast thyroid surgery were treated with complete medical records, confirmed by pathology in 30 patients with triple negative breast cancer, retrospective analysis of clinical and pathological features of patients, according to countries Drug Administration issued in 1994, "Chinese disease efficacy standards" to TCM syndrome of breast cancer into liver Tanning card, red card of any disorder, are three sets of virtual card Chi toxic syndrome, a variety of clinical pathology indicators in the traditional Chinese medicine syndromes in the expression of the situation and differences between the syndromes were analyzed in control, the use of statistical software, version SPSS17.0 for statistical analysis.Results:1,TNBC met the inclusion criteria were 41 cases of breast cancer cases over the same period (328 cases) 12.5%, according to exclusion criteria excluded 11 patients, 30 patients were included in the study. patients with an average age of 51 years, maximum 72 years of age, the minimum age 29 years, median age 49.6 years. Menopause Qian patients 18 cases (60%), menopause Hou patients 12 cases (40%), its histological type to infiltration sexual catheter cancer mainly, histological classification toâ…±level mainly, pathological staging toâ…±, andâ…²period mainly;2,syndrome differentiation in traditional Chinese medicine syndrome of liver Qi and coagulated phlegm (70%, flushes any disorders of liver syndrome of stagnation of phlegm syndrome 23.3% syndrome of deficient HIV blazing 6.7%), three group card type in onset age, and original made tumor, and pathological staging, and histological type, and histological classification, and P53, and Ki67 and the CK5/6 comparison in the no significantly sexual differences (P>0.05); liver Yu phlegm coagulation card group and are virtual HIV blazing card group in menopause State has significantly sexual differences (P<0.05), liver Yu phlegm coagulation card group and rushed any disorders card group in menopause State has significantly sexual differences (P<0.05), liver Yu phlegm coagulation card group patients more for is not menopause patients, and rushed any disorders card group and are virtual HIV blazing card group patients more for has menopause patients; Liver Yu phlegm coagulation card group and are virtual HIV blazing card group in lymph nodes State has significantly sexual differences (P<0.05), liver yu phlegm coagulation card group patients lymph nodes state N3 rare, and are virtual hiv blazing card group patients lymph nodes state are for N3, prompted are virtual hiv blazing card patients lymph nodes transfer rate than liver yu phlegm coagulation card patients high;3,menopause state and liver yu phlegm coagulation card of correlation has statistics significance (P<0.05): menopause state and liver yu phlegm coagulation card is are related (related coefficient 2.416), prompted more menopause qian of TNBC patients, syndrome differentiation card min type for liver yu phlegm coagulation card of ratio more large; lymph nodes state and are virtual hiv blazing card of correlation has statistics significance (P<0.05): lymph nodes state and are virtual hiv blazing card is negative related (related coefficient-1.754), prompted lymph nodes state more good, syndrome differentiation card min type for are virtual hiv blazing card of ratio more small, and lymph nodes state more difference, syndrome differentiation card min type for are virtual hiv blazing card of ratio more large; three group card type in onset age, and original made tumor, and pathological TNM staging, and histological type, and histological classification, and P53, and Ki67 and the CK5/6 and TNBC tcm syndrome differentiation card min type of correlation are no statistics significance (P>0.05).4,Triple negative breast cancer traditional Chinese medicine syndromes and CK5 / 6 expression was statistically significant (P = 0.006), liver syndrome Tanning CK5 / 6 expression is more negative and weak positive expression (78.9% share of the syndrome), is Chi-card virtual virus in patients with multiple positive and strongly positive (100% share of the syndrome.) Tanning is the virtual stagnation syndrome and toxic Chi-card in the CK5 / 6 expression was significantly different (P = 0.005), are virtual drug Chi syndrome CK5 / 6 non-negative expression, the liver syndrome Tanning CK5 / 6 No strong expression. CK5 / 6 and the certificate is false positive drug Chi, the correlation coefficient 19.270, suggesting that CK5 / 6 expression as possible, Syndromes drug Chi license false positive rate will be.Conclusion: Triple negative breast cancer in premenopausal syndromes that permit liver Tanning mainly in postmenopausal women with any maladjustment red card and is based virtual card Chi-toxic, is poisonous Chi-card virtual lymph node metastasis rate is higher than the other syndromes , Is the virtual card Chi-drug CK5 / 6 was higher than that of other syndromes. Menstrual status, lymph node status, and CK5 / 6 expression can be, respectively, as liver toxicity Tanning Chi virtual cards and certificates are dialectical objective indicators, other indicators of whether the objective of traditional Chinese medicine as a basis for TNBC need further prospective, large sample studies Results... |
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