The Clinical And Laboratorial Study On The Therapeutic Action Of Aescin In Hemorrhagic Apoplexy Brain Edema

Objective: To evaluate the clinical theraPeutic value and security of Aescin in hemorrhagic aPoPlexy cerebral edema with neurologic deficits through clinical trials.Methods:168 cases with hemorrhagic aPoPlexy brain edema were selected and were randomly divided into 2 grouPs, 86 cases of MTN treating grouP and 82 cases of XNJ control grouP. The results were assessed mainly by several indexes including the change of Swelling diameters, NIH Stroke Scale(NIHSS),Glasgow Coma Scale(GCS), and the amount of bleeding. Animal exPerimentation involved 2 models:SD male rats induced swell with egg white and male mice caused inflammation with dimethylbenzene, observed the ant-swell effect of MTN, and comPared with XNJ ;Animal exPerimentation did a test of acute toxicity of MTN on ICR mice, and calculated the LD50, then did a anaPhylaxis research with cavia, observed the anaPhylactic reaction.Results: Clinical studies showed that both grouPs could reduce the maximum diameter of hemorrhagic aPoPlexy brain edema and the NIHSS and the amount of bleeding, at the same time could enhance the GCS; Both the two grouPs with intravenous injection did not turn uP serious adverse reactions in the treatment of doses. Animal exPerimentation demonstrated that both grouPs could reduce the degree of the swell induced by egg white in SD rats and the inflammation caused by Dimethylbenzene in ICR mice, and without local anaPhylaxis.Conclusion:1.Aescin had good curative effect on hemorrhagic aPoPlexy brain edema with neurologic deficits, and Aescin had Positive significance in clinical treatment on the Patients with hemorrhagic aPoPlexy cerebral edema with neurologic deficits, the intravenous injection is safe in the treatment of doses. 2. Aescin had an inhibitory effect on the swell induced by egg white in SD rats and the inflammation caused by Dimethylbe- nzene in ICR mice, without anaPhylactic reaction.