The Characteristics Of Traditional Chinese Medical Syndrome After Controlled Ovarian Hyperstimulation In IVF-ET And The Disposition Rule Of Syndrome Type

Objective: To study the characteristics of Traditional Chinese Medical syndrome after controlled ovarian hyperstimulation in IVF-ET,then analyse the relevance between patient clinical material and syndrome,and have a research on the Disposition rule of syndrome type.Lay the foundation for Objectification and Standardization of Chinese medicine prescription and medication in corepus luteum support stage.Also provide both new ways and new train of thoughts for assisted reproductive technology field.Methods: In clinical study,280 infertile patients undergoing IVF-ET were studied using the method of literature researeh,epidemiologic method, expert consulation which combined with system cluster analysis to summary the characteristics of traditional chinese medical syndrome after controlled ovarian hyperstimulation in IVF-ET.Then group the patients into different categories by their syndrome characteristics.Using descriptive analysis, chi-square test and one-way ANOVA analysis to analyse and compare Generally demographic sociology factor, menstrual cycle, birth history, cause of disease, E2 level in blood serum on HCG injection date, number of oocytes ,OHSS incidence in different categories,clarify the relationship between factors associated and Syndrome after controlled ovarian hyperstimulation.Results: The results suggested that the deficiency of kidney with both qi and yin was the most common syndrome after controlled ovarian hyperstimulation.The second one was spleen-kidney yang deficiency,and the third was liver depression and qi stagnation with blood stasis. In general demographic sociology factors, age, education, nature of work did not show differences of the distribution of syndromes.The same to menstrual cycle in menstruation, marriage and childbearing history,and the numbers of pregnancies andabortions were on the contrary(P<0.05).In the research of etiology and syndrome distribution,the differences in constituent ratio made by causes of disease were significant(P<0.05),but whether have male factor was not make sense. The patients of four categories are different in levels of estrogen on HCG day,but number of oocytes is not show the differences.OHSS occurred or not had relationship with distribution of syndromes(P<0.05).Conclusion:The deficiency of kidney with both qi and yin and spleen-kidney yang deficiency had high proportion than other syndromes when the numbers of pregnancies≥3 times,and the deficiency of kidney with both qi and yin had high proportion than other syndromes when the numbers of abortions≥2 times. The patients which had ovulatory obstacle were tend to syndrome of spleen-kidney yang deficiency after COH,and patients had EMS were tend to syndrome of liver depression and qi stagnation with blood stasis. The levels of estrogen on HCG day was the lowest in category of kidney deficiency with both qi and yin.Patients with spleen-kidney yang deficiency syndrome had high tendency of OHSS incidence,and patients of kidney deficiency with both qi and yin were on the contrary.