A Rabblt Model Of High Energy Blast Injury On Abdominal Wall Combined With Wisceral Exposure

Objective:To establish a rabbit model of a high-energy abdominalwall blast injury combined with internal organs exposure, which can be,undertook long-term observation and observe causes of injury and healingrules.Method:12 white rabbits were divided into two groups randomlyand then marked in injured parts under general anesthesia conditions.Group A applied with self-made enterocoelia protective device, then used0.125 g TNT equivalent explosives ball directly stuck on the site of injury;Group B without any protective processing, used the same explosionsource to make the injury. After injured, we observed generally forms. Wetook tissues from every live animal's wound, and then did pathologicalobservation by time order. In addition, we recorded dead animals'survival time and preformed autopsy.Result:Both groups were examined. The examined area included all layers of the opened abdominal wall blast injury. The wound area ofexperimental group was 3.8±0.56 cm2, and control group was 3.93±0.49cm2 ( P > 0.05). There was insignificant difference between the twogroups. The survival time of experimental group was 142±87.78 h, andcontrol group was 3.77±2.25 h. (P < 0.05). There were significantdifferences between the two groups. The survival time of experimentalgroup was longer than control group. Autopsy and pathologicalobservation showed that the reasons of the early death in the controlgroup were abdominal bleeding and visceral injury, and the animals inexperimental group had not been seen obviously trauma on visceral. Eachlayer of abdominal wall tissues under explosion trauma was different.That appeared "Slight in superficial tissues, serious in deep tissues". Thepathological changes showed a progressive development. The typicalchange had been found in muscles.ConclusioConclusion:This experiment simulated the mechanism of abdominalwall blast injury. Through the effective protection,we established a kindof animal model of the simple abdominal wall blast injury, which couldsurvive longer after injury.