Clinical Significance Of Serum Levels Of Protein And Coagulation Indexes In Pregnancy-related Hypertension

Objective To explor the clinical significance of serum protein levels and coagulation indexes in hypertensive disorders in pregnancy(HDP).Methods 1. Serum levels of total protein(TP), albumin, globumin and clinical data were analyzed in19 cases of gestational hypertension(GH),22 cases with mild pre-eclampsia(MPE),27 cases of early onset severe pre-eclampsia(EOSP),21 cases with late onset severe preeclampsia(LOSP) and 18 cases of normal late pregnancy women(NLP).2. Blood platelet count (PLT), PT, APTT, TT and fibrinogen (FIB) level were analyzed in 21 cases of gestational hypertension, (GH),26 cases with mild pre-eclampsia(MPE),24 cases of early onset severe pre-eclampsia(EOSP),26 cases with late onset severe pre-eclampsia(LOSP) and 20 cases of normal late pregnancy women(NLP).Results 1. Serum levels of TP were gradually decreased in NLP, GH, MPE, LOSP and EOSP groups, there were significance differences among EOSP, NLP and GH groups (P<0.001), and there were also significance differences between LOSP and NLP groups (P<0.05).Serum levels of albumin were also gradually decreased, and there were significance differences among EOSP, LOSPS and GH groups (P<0.001). Serum level of globumin was markedly decreased in EOSP group, there was significance differences between EOSP and NLP groups (P<0.001). Hypoproteinemia rates were gradually increased and there were significance differences among EOSP and other groups (P<0.001)2.PLT was markedly lower in EOSP group than that of LOSP group, there was significance differences(P<0.01), the rate of thrombocytopenia was 50% in EOSP group; the PT and APTT were lower in EOSP than that of LOSP group,there were no significance differences, but TT was hihger in EOSP group; the level of FIB was significantly decreased in EOSP gorup than that of LOSP group, and there was significance differences(P<0.01).Conclusion 1.Serum albumin levels is a significant determinant of disease severity in pregnancy related hypertension, and may be considered as a useful marker for predicting to severity of pre-eclampsia.2.PLT and level of FIB were significance decreased in EOSP group and it's a important determinant of disease severity, but the PT,APTT and TT can not reflect the severity of hypertensive disorders in pregnancy.