The Preparation Of Yigan Granules Technology And Quality Standards

Hepatitis B, also known as serum hepatitis, hepatitis B (HBV for short), is by the hepatitis B virus (HBV) caused a worldwide disease.Currently, there are 30 million hepatitis B patients. Most patients with no clinical symptoms of hepatitis B, only 1/3 of the clinical manifestations of hepatic damage occurred. The most obvious of hepatitis B liver disease, diffuse throughout the liver. Basic lesions of liver cell degeneration, necrosis, inflammatory cell infiltration, liver regeneration, fibrosis. The final status of hepatitis B cirrhosis. The hepatitis B virus infection in patients with cirrhosis may develop liver cancer. Hepatitis B patients have cause to live, work and normal interpersonal inconvenience caused, and its post-treatment costs for both the patients or their families as a great economic costs. Therefore, prevention and treatment of hepatitis B is important.Yigan granule is Chinese medicine clinical treatment of acute and chronic hepatitis B stasis heat of effective parties, which is is composed by Salvia, Flavescens and Schisandra.To facilitate the drug, increased drug stability, the subject of scientific research through the system to system more patients into the new Chinese medicine for use. Methods:Traditional Chinese medicine theory as the guiding principle, according to prescription medicines and Indication and nature, combined with Chinese drug research of the requirements, use of modern preparation technology, more and orthogonal test method used to study the preparation process to determine Yigan granule and its quality standards; and sample observation method used to stay the preliminary investigation of their stability. Results:The best preparation technique selected:Salvia to 8 times the amount of 80% ethanol reflux for 3 times, 1h, combined liquid, filtration, the filtrate was below 60℃and decompression recovery of ethanol, concentrated into a relative density of 1.02～1.06 clear grease. Salvia Sophora flavescens and residue after ethanol plus 10 times the amount of co-boiling water 3 times, each time 1h, combined decoction of all times, to the appropriate concentration, volume of ethanol to 55% with alcohol, standing 24h, filtration, the filtrate vacuum recovery of pure alcohol without flavor. Will merge the two clear cream mix, condensed, dry, powder made from dried extract add Schisandra powder, granulation, whole, dried, be finished. Conclusion:The results showed that the liver and granule preparation reasonably practicable, controlled quality standards, product quality stable...