Study On Compattible Stability Of Shuanghuanglian Powder Injection And Common Injection In Vivo And In Vitro

Objective:Study the compatible stability of shuanghuanglian powder injection and common injection in vivo and in vitro, increasing the accuracy to resolve adverse effects of Chinese medicine injections and ensuring the clinical safety of drugs.Method:The samples of complexes with the Sodium chloride solution as a solvent were collected at room temperature to study the changes of appearanc, pH and to determine content of baicalin, chlorogenic acid by using HPLC method. The data obtained were fitted with Practical Pharmacokinetic Program-Version97(3P97). By comparing single agent and combined pharmacokinetic parameters after the shows, the mean serum concentrations of baicalin and Chlorogenic acid after iv Shuanghuanglian or mixed drugs in rats were fitted to a two-compartment model with a weight of 1/C2.Result:Firstly, the compatibility of the liquid appearance: ShuangHuangLian plenty licensing injection for denitration thiazole glucose injection with calcium gluconate, injection, hydrochloric acid epinephrine injection, cimetidine mesylate rescriptor afraid bead injection, sodium chloride injection uptake after the compatibility of appearance, pH value solution without opparent change, and cefuroxime sodium bicarbonate sodium plenty licensing injection, after injection color burn and compatibility of bubble produce. Secondly, compatibility with plenty licensing injection ShuangHuangLian liquid pH:calcium gluconate injection, hydrochloric acid epinephrine injection, cimetidine mesylate rescriptor afraid of injection, sodium chloride injection, pearl sand plenty licensing injection, cefuroxime sodium bicarbonate sodium injection compatibility with no obvious change, pH paclobutrazol glucose injection for compatibility (pH) is changed. Thirdly, compatibility with liquid particles:ShuangHuangLian plenty licensing injection injection, sodium bicarbonate calcium gluconate injection, hydrochloric acid epinephrine injection, cimetidine mesylate rescriptor palmer bead injection, sodium chloride injection compatibility uptake in accordance with the provisions after the number of particles; ShuangHuangLian plenty licensing injection and imidazole glucose injection, for denitration plenty licensing injection cefuroxime sodium compatibility within the prescribed scope after the number of particles. Lastly, ShuangHuangLian compatibility liquid content: plenty licensing injection and cefuroxime sodium levels in plenty licensing injection compatibility. The main pharmacokinetic(PK) parameters of baicalin and Chlorogenic acid in two groupswere as follows, andrespectively:baicalinα=0.049min-1 and 0.052min-1, p=0.014min-1 and 0.017min-1, K21=0.015min-1 and 0.021min-1, K12=0.0019min-1 and 0.0021min-1, T1/2(β)=48.68min and 47.68min, AUC=3.85(μg/mL)·min and 3.90(μg/mL)-min. Chlorogenic acid a=0.034min-1 and 0.032min-21,β=0.021min-1 and 0.027min-1, K21=0.021min-1 and 0.031min-1, K12=0.000046min-1 and 0.000067min-1, T1/2(β)=32.25min and 31.37min, AUC=15.68([μg/mL)·min and 15.35(μg/mL)·min.Conclusion:Shuanghuanglian powder could not combine with cefuroxime sodium powder for injection, Glucose injection with Tinidazole or Sodium bicarbonate injection. but can combine with other drugs.