Correlation Of Dynamic Contrast DCE-MRI With Vascular Endothelial Growth Factor And Blood Stasis Syndrome In Breast Cancer

Objective:To observe the correlation of dynamic contrast-enhanced MRI(DCE-MRI)appearances, and vascular endothelial growth factor (VEGF) expressions, and the blood stasis syndrome in breast cancer. According to evaluate before operation and guide treatment of comprehensive therapyMethods:From Sep.2008 to March.2011,33 Patients with breast lesions detected by Physical examination or mammography underwent MR examinations on a 1.5T scanner (Siemens Avanto) Preoperatively. MR examinations included 8 min 3D DEC—MRI by VIBRANT sequence. Evaluate Preoperation blood stasis degrees. VEGF expression were detected by immunohistochemical in 33 operative pathologic specimen of breast cancer. DCE-MRI time-intensity curves of the lesions were classified as type I(steady enhancement), typeⅡ(plateau)and typeⅢ(washout). Lesions with typeⅠwere classified as benign, whereas the lesions with typeⅡor typeⅢwere classified as malignant. Statistically, analyze the correlation of DCE-MRI appearances (tumor size, shape, spicular signs, enhancement patterns, TIC type)with VEGF and blood stasis syndrome in breast cancer by SPSS13.0.Result:33 Patients with breast lesions detected by 1.5T scanner, The leision which has speculated margin, skin thickening and edema, nodes with a diameter of more than lcm can be diagnosed by MR rout-scanning direetly. There is a positive correlation and significant difference in statistic between DCE-MRI and VEGF expression. There is stronger positive rate in V>1.5%. There is no difference in statistic between the other DCE-MRI appearances and VEGF. Correlation of DCE-MRI with the blood stasis in breast cancer:There are no differences in statistic about the DCE-MRI appearances in blood stasis syndrome and additional syndrome.Conclusion:The combination of dynamic contrast-enhanced MRI and VEGF useful to increase spectivity. DCE-MRI appearances responds to the blood stasis degree of breast cancer. and can provide valuable and affluent information for the diagnosis of those Leisions suspicious in dynamic contrast-enhanced MRI.