Observation Of Curative Effect Of QingChangHuashi Method Treating Ulcerative Colitis Patients In Active Stage

Objective:The aim of this study is to observe the clinical effect of QingChangHuaShi method treating ulcerative colitis(UC), and to explore the mechanism of this method from the point of traditional Chinese medicine and Western medicine.Method:90 patients who were diagnosed as in active stage of UC by colonoscopy and diagnosed as the syndrome of internal stasis of dampness and heat by syndrome differentiation of traditional Chinese medicine were divided into three groups. In the first treatment group,30patients were treated with taking QingChangHuaShi prescription; in the second treatment group,30 patients were treated with taking QingChangHuaShi prescription in combination with retention with enema prescription; the other30 patients in the control group were treated with particle release mesalazine (5-ASA). Three months later when the treatment is over, compare the clinical curative effect and monitor the safety index.Results:The total effective rate of the first treatment group is 80.0%, the total effective rate of the second treatment group is 93.3%, while that of the control group is 83.3%. The effective rate of the second treatment group is superior to the other 2 groups(P<0.05), and there is no statistic difference in comparison of the first group and the control group (P>0.05). The integration of colonoscopy and symptoms has improved after treatment, compare the results of colonoscopy and symptoms of these groups and find that the second group is superior to the other 2 groups (P<0.05). The first treatment group is not superior to the control group(P>0.05).Conclusion:The curative effect of taking QingChangHuaShi prescription in combination with retention enema treating ulcerative colitis patients in active stage is superior to that of 5-ASA, and is also superior to that of taking QingChangHuaShi prescription alone, especially in improving TCM or clinical syndrome,intestinal mucous membrane. And the QingChangHuaShi method of traditional Chinese medicine is safe.