Cluster Analysis Of Traditional Chinese Medicine Syndromes On Sleep Apnea Syndrome

Objective:(1)The study was to explore the SAS distribution rule of traditional Chinese medicine(TCM) and provide some theoretical evidence for determination of treatment based in pathogenesis obtained through differention of symptoms and signs. (2)To discuss the relationship between the characteristics of TCM syndromes and the different illness degree of SAS.Methods:146 SAS patients who met the inclusion criteria in respiratory Outpatient and Inpatient Department from The Second People's Hospital affiliated to Fujian University of TCM during July 2009-December 2010 were selected into the study. We noted all patients' messages about sex,age,occupation,personal history,main clinical manifestation, tongue and pulse manifestation,physical examination;And applied SPSS13.0 statistics software to establish 146 cases item database about individual information,then applied hierarchical cluster analysis to symptom item. Professors were maked up as expert group, who discussed and modificated the initial model by cluster analysis, thus, established the denotation of pattern of syndrome.Main Results:1.146 patients who were collected integrated information (Male/Female:136/10, mean age: 45.27±12.68 years) were assessed.79 patients have a smoke(54.11%) and 76 patients take a horn(52.05%). The complications of SAS were:hypertension (n=49,33.56%), diabetes(n=11,7.53%), hyperlipidemia(n=65,44.52%), vasculopathy of heart and brain(n=37,25.34%).2. The finding of types of TCM symptom according to cluster analysis were:stagnation of phlegm-dampness syndrome(n=21,14.38%), phlegm-heat lying depressed in the lung and spleen and kidney deficiency syndrome(n=46,31.51%), liver-yang hyperactivity and phlegm blocking syndrome(n=42,28.77%),kidney deficiency and blocking of phlegm, heat and petechia syndrome(n=37,25.34%).3. The TCM distribution of different level condition adout SAS:Liver-yang hyperactivity and phlegm blocking syndrome was the main percentage in mild SAS. Phlegm-heat lying depressed in the lung and spleen and kidney deficiency syndrome and kidney deficiency and blocking of phlegm, heat and petechia syndrome were malariaed in moderat and severe SAS.Conclusions:1. The result of the cluster analysis is that 4 tradtional Chinese medicine symptoms are inclued in SAS:stagnation of phlegm-dampness syndrome;phlegm-heat lying depressed in the lung and spleen and kidney deficiency syndrome;liver-yang hyperactivity and phlegm blocking syndrome; kidney deficiency and blocking of phlegm, heat and petechia syndrome. 2. Liver-yang hyperactivity and phlegm blocking syndrome was the main percentage in mild SAS. Phlegm-heat lying depressed in the lung and spleen and kidney deficiency syndrome and kidney deficiency and blocking of phlegm, heat and petechia syndrome were malariaed in moderat and severe SAS.