Comparison Of Patient Controlled Intravenous Analgesia With Dezocine And Sufentanil Following Resection Of Colon Cancer

Background and ObjectiveWith the rapid development of society and comfort of health care evolves, people's medical philosophy is changing, is widely recognized that "No pain is patients' rights, Analgesic is doctors'duty". The time of first aid or life settlement life extension, and the relative neglect of fear of pain has passed. In recent years, pain in clinical practice has become the fifth vital sign after the body temperature, pulse, respiration, blood pressure. How to fast, safely and effectively control the postoperative pain is not only a medical problem which medical workers has been unremitting efforts to resolve, but also a s social problems which trouble patients and their families.Postoperative pain is a common type of pain,it is found in almost all patients after surgery. The postoperative of colon cancer endure severe pain, surgery brings them not only the enormous physical and psychological suffering, it also led to a series of multiple systems in patients with systemic change, and even induced cardiovascular and cerebrovascular accidents; and the braking caused by fear of pain increased the incidence of postoperative complications,such as perioperative deep vein thrombosis, pulmonary infections, bed sores, etc.lt serious impact on perioperative patient quality of life and body recovery. Therefore, a good postoperative analgesia is very important.Currently, fentanyl and sufentanil are the primary clinical analgesic drugs which commonly used in abdominal surgery, but the nausea, vomiting, respiratory depression, excessive sedation and other adverse reactions limit the using of these drugs in clinical application. Dezocine is a new drug of opioid analgesic,it mainly through activationκreceptors produces analgesia, while it excited-antagonistsμreceptors.It makes strong analgesic effect, and is safety and well tolerated. Currently, the domestic research about dezocine used in patient controlled intravenous analgesia is less. This stduy is to compare the efficacy and safety of dezocine and sufentanil in patient-controlled intravenous analgesia to colon carcinoma resection.Materials and Methods60 ASAⅠ～Ⅱpatients undergoing elective resection for colon cancer were randomized into 2 groups,who received PCIA with dezocine 0.8mg/kg(group D), 2μg/kg sufentanil(group S).The efficacy and side effects including nausea, emesis, lethargy and respiratory depression were evaluated by VAS scores and Ramsay scores at 3,6,12,24,48 hours after operation.Statistical analysis is performed SPSS 17.0 software. Measurement data are expressed as x±s.and use t test; Count data are expressed as percentage and useχ2 test.P<0.05 is considered statistically significant.Results1. The differences of patients 'age, weight, sex, operative time, blood loss, between two groups are not considered statistically significant (P> 0.05). All patients had been completed the operation successfully by the same group of surgeons.2. The postoperative VAS pain score and push the pump in the number of 48h are no significant difference (P> 0.05).3. Group D 3h,6h,12h,24h of the Ramsay scores are significantly lower than the S group (P<0.05).4. The differences of nausea and vomiting between two groups were are not considered statistically significant (P> 0.05); D group drowsiness, respiratory depression are significantly lower than the S group (P<0.05).Conclusions1. Dezocine(0.8mg/kg)in PCIA following resection of colon cancer exhibits good effect of analgesia.2. Dezocine(0.8mg/kg) and sufentani(2ug/kg) are used alone in PCIA following resection of colon cancer, Dezocine brings lower incidence of adverse reactions and is safer.