Retrospective Comparison Of The Systemic Response After High-Intensity Focused Ultrasound Ablation

Objective:To analyze the alterations of clinical parameters after High-intensity focused ultrasound (HIFU) ablation on benign and malignant tumors.Methods:A total of 71 patients with tumors received 99 HIFU treatments. Several major hematologic and biochemical parameters were tested 1 day after HIFU treatment.Results:The major indicators of liver function, renal function and CBC were not significantly changed after HIFU treatment. However, compared to the parameters tested before HIFU treatment, the percentage of patients with low fever (body temperature above 37.5℃) and elevated CRP increased significantly (p<0.05). CK and CK-MB levels also increased from 57.89±31.05 U/L and 13.80±9.79 U/L to 472.23±507.56 U/L and 21.51±10.09 U/L 1 day after HIFU treatment(p<0.001). The percentage of patients with CK elevation was significantly higher using the anesthesia treatment mode compared to the non-anesthesia mode (p<0.001).Conclusions:HIFU is a promising choice for tumor treatment with minor influences on liver, renal and hematopoietic functions, though it indeed induces low fever and elevation in CK and CRP.