The Association Between IL-17 G-152A, 7383A/G Polymorphisms And The Susceptibility Of Myasthenia Gravis

Object:The aim of this study is to display the relationship between the IL-17 G-152A,IL-17 7383A/G polymorphisms and susceptibility to myasthenia gravis.Exploring the genetics background and pathogenesis of myasthenia gravis will provide theoretical basis for the diagnosis and treatment of myasthenia gravis.Methods:This experiment used case-control study.128 MG patients from the south China regions who were diagnosed through the clinical features and laboratory tests were collected from XiangYa Hospital,while the controls were patients who had not immunity disease or healthy individuals.IL-17 G-152A,7383A/G polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Result:1.In the controls,the frequencies of IL-17 G-152A genotypes were AA 20.7%,AG 53.3%,GG 26.0%,the frequencies of A/G allele were A 47.4%,G 52.6%;IL-17 G-152Agenotypes were AA 91.9%,AG 8.1%,GG 0%;the frequences of A/G allele were A 95.9%,G 4.1%.2.IL-17 G-152A polymorphism revealed no significant difference of genotype and allele distribution in MG patients and controls. 3.IL-17 7383A/G polymorphism revealed significantly differences of genotype and allele distribution between MG patients and controls(P< 0.05).IL-17 7383A/G AG genotype was associate with a higher susceptibility of MG patients over 40 years old than controls(OR=4.581, 95%CI=1.711～12.263, P=0.01).4.Linkage disequilibrium was found between IL-17 G-152A and IL-17 7383A/G.But there were significant difference of halotypes distribution bertween the patients and controls.Conclusions:1.There was no significant difference between IL-17 G-152A polymorphism and MG in Han people of South China.2.IL-17 7383A/G polymorphism was associated with the susceptibility of MG in Han people of South China.It suggested that IL-17 7383A/G G allele might be a susceptibility genetic factor for MG.