The Alteration Of Serum CA19-9 Levels In Patients With Diabetic Ketoacidosis

AIM:To retrospectively observe serum CA19-9 levels in patients with diabetic ketoacidosis (DKA) compared to diabetics without DKA.METHODS:73 patients with DKA (DKA group.39 type 1 and 34 type 2) and 209 diabetics under dissatisfied glucose control (Non-DKA group.HbA1c>7.5%,30 type 1 and 179 type 2) were enrolled.Records of sex,age.diabetic duration.BMI,HbAlc.CA19-9 level were collected. The levels of serum CA19-9 were compared between the two groups. Multiple regression was done to analyze the correlation between different variables and CA19-9 levels.Further analysis was performed in the DKA group by dividing the patients into subgroups of type 1 and type 2 diabetes. RESULTS:Average CA19-9 level was significantly higher in DKA group(54.67±91.12U/ml) than in Non-DKA group(16.76±22.23U/ml.P<0.01).as well as the percentage of positive CA19-9 level(37.9% and 7.7%,P<0.01).The abnormal values were in range of 37.1U/ml-674.5U/ml, mainly distributed within 200U/ml(95.6%). Multiple regression analysis showed a positive correlation between HbAlc and CA19-9 level.and whether with DKA state is another factor correlated.there was negtive correlation between age and CA19-9 level.while no correlation between CA19-9 and BMI or the duration of diabetes were found.The rate of CA19-9 elevations in typel and type2 subgroups were 56.4%(22/39) and 20.9%(7/34.P<0.0).respectively.The average CA19-9 level was 80.51±118.31U/ml (range 41.1-674.50U/ml)±in type1 subgroup compared to 25.04±17.40U/ml(range 37.1-70.6U/ml.P<0.01)in type 2.CONCLUSION:Slight to moderate elevations of CA19-9 levels are more frequently found in DKA patients than diabetics under poor glucose control.as well as significant higher levels.HbAlc and whether in DKA are both correlated to CA19-9 level.In addition.type 1 diabetic patients seemed more likely to appear increased CA19-9,and the value was higher compared to type 2 diabetic under the condition of ketoacidosis.CA19-9 elevations may stand for the demage exist in the exocrine pancreas with the diabetic basis and episode of DKA.