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Studies On Novel Mussel Biomimetic Polyurethane Materials

Posted on:2012-10-17Degree:MasterType:Thesis
Country:ChinaCandidate:X YaoFull Text:PDF
GTID:2211330362959555Subject:Materials science
Abstract/Summary:PDF Full Text Request
Recently, the marine mussel drawed much attention. In order to attach to surfaces like rock, reef, coral and hull, mussels secrete special adhesives named mussel adhesive proteins (MAPs) in the underwater enviroment. A common character of the MAPs is that they possess a relatively high level of L-3,4-dihydroxyphenylalanine (DOPA), a catabolic amino acid produced from post-thanslational modification of tyrosine. Research carried out by other groups suggests that the catechol group in DOPA plays an important role in enhancing interfacial adhesion. In this study, we combined the adhesive property of catechol group and the biocompatibility of polyurethane together and developed a novel biomaterial to explore potential applications in tissue engineering. A dopamine-containing diamine LDA was first synthesized, which was spontaneously adopted as a chain extender in polymerization. The successful synthesis of LDA and the incorporation of dopamine with polyurethane was confirmed by FTIR,1H NMR, TOF-MS and GPC.The results of DSC showed that the synthesized polyurethanes were more likely to crystallize with the increase of the molecular weight of soft segment. According to TGA results, the thermal decomposition of hard segment and soft segment in polyurethane appeared at 300oC-350oC and 370oC-470oC, respectively. AFM images indicated that phase-separation existed on the surface of polyurethanes and confirmed the crystalline structure. In the presence of lipase, polyurethanes degraded as expected, and the degradation behavior of PCL2000-LDA and PCL3000-LDA was more obvious than PCL1000-LDA. From the cell affinity tests, it was acknowledged that the introduction of catechol group could enhance cell adhesion, and cells distributed well on the surface of polyurethanes.
Keywords/Search Tags:tissue engineering materials, polyurethane, mussel biomimetic, human umbilical vein endothelial cell (HUVEC)
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