Nmr Spectroscopy Invasive Blood Glucose Measurement, Signal Processing And Algorithm Optimization

Diabetes is due to kinds of pathogenic factors such as genetic factors, immune disorders, microbial infections, free radical toxins, mental factors that act on the body leading to insulin secretion or insulin resistance caused by a hormone disorders.One of the major treatment techniques for diabetics is to monitor their blood glucose levels in real time. Presently, most diabetics are using invasive glucose detection equipment to monitor their own blood sugar level, this method has many disadvantages, such as patients likely tend to generate resistance because of pain and the cuts for extracting blood are easily causing infections. Therefore, many research institutions propose their own non-invasive blood glucose detection methods. Views of the present research are that using infrared spectroscopy for noninvasive blood glucose monitoring is a relatively mature technology.This paper presents a new non-invasive method for blood glucose monitoring systems based on proton nuclear magnetic resonance of non-invasive blood glucose monitoring; the paper first outlined the principle of magnetic resonance and magnetic resonance techniques using quantitative measurement methods for material. After that, the article makes a detail on the NMR magnetic field, RF transceiver coil, the control circuit and gives practical introduction to the design of magnetic resonance equipment device as well as the picture. Finally, the paper makes a specific description on the acquisition and processing of the real-time magnetic resonance signal as well as spectrum analysis.The real time acquisition system in the article is based on the MATLAB which connect the oscilloscope and the computer, in this system, the high sample rate oscilloscope is working as a signal acquisition and analog-digital conversion module connecting directly with the computer. Because of this research project is still in the feasibility study stage, so this paper uses MATLAB to simulate the free induction decay signals from the magnetic resonance equipment, adds the actual noise based on actual situation and design the corresponding filter to process the signal. Signal spectrum analysis results show that the NMR method can clearly show the different of the spectrum based on the different ratio between glucose and water solution, also it proves that noninvasive blood glucose detection system which uses the nuclear magnetic resonance method is feasible. At the end, this article details the current research shortcomings and future research directions, and proposes the suggestion to continue for the further development of this project.