Experimental Study Of The Congestion Status Of Ulcerative Colitis (platelet Activation)

The ulcerous colitis (ulcerative colitis, UC) is on clinical common digestive tract disease, is a kind of cause of disease not yet the completely explicit intestinal tract non-specificity inflammation. At present, mainly concentrates to the UC cause of disease and pathogenesis's research in the immunity factor, the hereditary factors, the environmental factor and other pathogenic factor. In recent years studied indicated that ulcerous colitis patient in vivo has the blood to congeal the condition, the risk which the thrombus occurred increases, prompts the micro thrombus the formation is possibly one of high UC important pathogenesis. Domestic and foreign reports, blood platelet, in lies between leads the inflammation to respond and the thrombus forms the influential role, the activation blood platelet can also produce the oxygen free radical to cause the organization to damage. Therefore, the blood platelet activated in the UC morbidity the function has aroused people's interest. The Chinese medicine basis"long illness enters winds","long illness must have the stasis"the theory, thought that the vitality stasis stagnates, in the ulcerous colitis occurs has the specially vital significance, and is closely related with disease's activity. This experiment the angle which activates from the blood platelet, examined each target which the UC patient in vivo blood platelet activates, finally the UC patient's platelet count (PLT),the blood plateletаpellet membrane protein - 140(GMP-140), thrombus element B2(TXB2) is higher than the normal person, P<0.05;The blood platelet average volume (MPV) is lower than the normal person, P<0.05.Simultaneously the UC patient's platelet count (PLT), the blood plateletаpellet membrane protein - 140(GMP-140), thrombus element B2(TXB2) presents separately with disease's activity related, the blood platelet average volume (MPV) assumes the inverse correlation with disease's activity. Explained in the UC morbidity process has the ecchymosis,and the ecchymosis and disease's activity is closely related. This experiment has further known the ulcerous colitis's pathogenesis, not only for judgment ulcerous colitis whether to have the ecchymosis to provide the powerful laboratory basis, further rich Chinese medicine theory; May also to weigh the Chinese medicine treatment ulcerous colitis's curative effect to provide the reliable standard,even more expands the Chinese medicine to treat UC the mentality.