Three Types Of Structural Transformation Of The Natural Compounds

This dissertation is composed of four parts.Part A described the structure modification and activity screening of diterpenoids from Hedychium yunnanense Gagnep.Part B described the structure modification and activity screening of simplified analogues of yunnancoronarin A.Part C reported the structure modification of genipin.Part D described the structure modification and activity screening of oleanolic acid.The structure modification and biological activity research of oleanolic acid were summarized. Part A The structure modification and activity screening of diterpenoids of Hedychium yunnanense GagnepThis part reported using the oxidation-reduction reaction to obtain the derivatives of hedychenone.Hedychenone is a diterpenoid from Hedychium genus,it contains furan,one double bond and ketone,structure modification of the compound offorded a series of derivatives and biological activity screening were carried out.Part B The structure modification and activity screening of simplified analogues of yunnancoronarin AThis part reported the method of synthesis of simplified analogues of yunnancoronarin A.And determined cytotoxic of the simplified analogues.Part C The structure modification of genipin derivativesThis part reported the methods of modificating genipin derivatives.The methods introduced to prepare the structure modification were listed below:(1) Reaction of S22 and acetic anhydride;(2) Reaction of S23 and hydrogen.Part D The structure modification and activity screening of oleanolic acidThis part reported the methods of synthesis of oleanolic acid derivatives.The methods were listed below:(1) Reaction of oleanolic acid and PCC;(2) Reaction of oxide of oleanolic acid and 2,4- dinitro-phenyl-hydrazine;(3) Reaction of oleanolic acid and TsCl.And determined antineoplasmic activity of 3 derivatives.