Gspe, It Was On The Impact Of Movement In Rat Myocardial Metabolism Of Free Radicals And Exercise Capacity

1 Objective:The key point of this paper is to observing Training exercise and taking grape seed proanthocyanidin extract(GSPE) on myocardial free radical metabolism and exercise capacity, investigate the effect by GSPE on inprove the antioxidant capacity and exercise capacity,in order to give a better guide to the training exercise,and provide a scientific basis for enhance the capacity of sports and explore a antioxidant drugs.2 Method:Select 120 wister mice(meas.96),8-week-old.randomly divided into four groups:A group (control group),B group(medication group),C group(exercise training group),D group (medication group exercise).C,D group rats give eight weeks of swimming training,B,D group give GSPE every day.Eight weeks later,all mice were randomly divided into three different subgroups in accordance with the different executed status,namely:quiet group,instantly exhaustive group,exhaustive 24-hour Recovery Group.And the corresponding execution time broken heart.after the determination of MDA content in check,SOD activity,GSH-PX activity, XOD activity,GSH content and total antioxidant capacity.Measured data SPSS10.0 statistical software to conduct an independent samples T-test,compared with the control group were significantly different,P＜0.05.a very significant difference,P＜0.01.3 Result:3.1 In Quiet state,myocardial MDA content lower than the A group B group(P＜0.05),D group was significantly lower than C group(P＜0.01).SOD activity in group D was significantly higher than A,B group(P＜0.01),D group was higher than C group(P＜0.05),the other groups no significant difference(P＞0.05).GSH-PX activity in B,C group was higher than A group(P＜0.05),D group was significantly higher than the A group(P＜0.01),D group was higher than B, C group(P＜0.05).GSH content of B,C,D group was significantly higher than the A group(P＜0.01),D group was higher than C group(P＜0.05).D group was significantly higher than the B group(P＜0.01).XOD activity of D slightly lower than the other three groups but no significant difference between groups(P＞0.05),A,B,C group no significant difference(P＞0.05).Total antioxidant capacity higher than the A group B group(P＜0.05),C,D group was significantly higher than the A group(P＜0.01),D group was significantly higher than the B group(P＜0.01), D group was higher than C group(P＜0.05).3.2 At the immediate ends of exhaustive exereise,the MDA content of myocardial B,C,D group was significantly lower than A group(P＜0.01),D group was significantly lower than C group(P＜0.01).SOD activity in group B than A group(P＜0.05),D group was significantly higher than the A,B,C group(P＜0.01).GSH-PX activity in group D was significantly higher than A,C group(P＜0.01),B,C group was higher than A group(P＜0.05).GSH content of B,C, D group was significantly higher than the A group(P＜0.01),D group was significantly higher than the C group(P＜0.01) D group was higher than B group(P＜0.05).XOD activity of B,D group than in A group(P＜0.05),A,C group no significant difference(P＞0.05).Total antioxidant capacity B,D group was significantly higher than the A group(P＜0.01),D group was significantly higher than the C group(P＜0.01).3.3 At the 24 hours ends of exhaustive exercise,the MDA content of myocardial B,D group than in A group(P＜0.05),D group was lower than C group(P＜0.05).SOD activity in B,D group was significantly higher than the A group(P＜0.01),D group was significantly higher than the C group(P＜0.01),D group was higher than B group(P＜0.05).GSH-PX activity in group B than A group(P＜0.05),D group was significantly higher than the A,C group(P＜0.01).GSH content of B,C,D group was significantly higher than the A group(P＜0.01),D group was significantly higher than the B group(P＜0.01),D group was higher than C group(P＜0.05). XOD activity of C,D group than in A group(P＜0.05),A,B group was no significant difference (P＞0.05).D total antioxidant capacity was significantly higher than the A,C group(P＜0.01),A, B,C group no significant difference(P＞0.05).3.4 The Exhaustive time,D rats exhaustive time compared with A,B were significantly increased(P＜0.01).B Group A Group to extend the comparison(P＜0.05),D group compared to extend the C group(P＜0.05).4 Conclusions:4.1 Eight weeks of aerobic endurance training to improve the state of each rat myocardial tissue antioxidant capacity,and enhance enzymatic system to the protective effects of myocardial cells of cardiac tissue cells play a good protection.4.2 Proanthocyanidins reduce free radical scavenging active lipid peroxidation showed a greater advantage,and organizations can improve myocardial antioxidant capacity is conducive to the protection of the myocardium.4.3 Aerobic endurance training in the use of the Joint proanthocyanidins can be an effective way to remove free radicals in myocardial tissue production,lipid peroxidation inhibition, extension of time for rat movement and improve exercise capacity.