Summer Capsule Preparation And Quality Standards

Insomnia is one of the common diseases in clinical,which such as palpitations,chest,dizziness,stroke and other internal medical diseases can be induced or exacerbated by,although it doesn't belong to critical illness.Refractory insomnia brings the patients serious psychological burden and emotional distress,reducing the impact of its work and the quality of life.Contained in the "lin-lan pandect to be newly revised," the "ShuangXia Tang(Pinellia,Prunella vulgaris)" is widely used in the treatment of insomnia,complying to the vicissitudes of natural law of yin and yang and coinciding the rhythm of movingin ying and wei cycles of human body.According to clinical needs of insomnia,consulting a large number of documents,I found a pair of medicine to treat insomnia through the ancient practice of medicine and the test of independent activity in mouse,Shuanxia capsules were preliminarily verified its efficacy of tranquilize and built into capsule Total alkaloid content was as an index to study the conditions of its preparation into a capsule preparation.The qualitative and quantitative analysis methods were developed to control the inherent quality of formulation.1,Effects of Shuangxia capsules independent activity in mouse was no significant differences in effect of Tongren' zaorenanshen oral liquid. Through the subsection screening,we finally found 75%ethanolic extract made the most efficacy of tranquilize,followed by ethyl acetate. Therefore,in order to maximize the effects,75%of ethanol extraction was determined.Then it was prepared for the next preparation capsule.2,Make sure the extraction of total alkaloids inspection methods.The alkaloid was extracted by chloroform from Pinellia ternate and tested at 415nm with the spectroscopy by acid dye.Based on the studies of the influence factors,we optimized the condition,choosed the best method of acid dye which influenced the determination the content of the alkaloid.Total alkaloids as the best evaluating indicator of the inspection process,and optimized the process parameters.We produced the ShangXia capsules.3,TLC methods were used to identify pinellia ternate and Spica prune- llaein fomula in ShuangXia capsules.The method Of UV was used for alkaloid in Pinellia ternate.At the same time,a methodological study was inspected. The results of method is accurate,and reproducibility is good. The recovery rate is 100.94%,RSD = 2.96%.The method of HPLC for Ursolic acid was preliminary developed to determine its contents in preparation, inspecting a methodological study.The results of method is accurate, and the reproducibility is good.The recovery rate is 99.06%,RSD=2.76%.In this study,the indicators of evaluating the preliminary pharmacyodynamics established Shuangxia capsules active site.The indicators of acid dye colorimetric assay for total alkaloids determined the preparation process,and developed a more comprehensive quality standards.Then it had laid a certain foundation for the future further study.