Cirrhosis Constitution And Principles Of Treatment Of Chronic Liver Disease

It is a complicated process to form hepatic cirrhosis,which is many chronic liver diseases' co-histological change.Many factors can induce hepatic cirrhosis,such as the activation of many cells in liver,the generation of HSC, excessive deposition of ECM,more secrete of CK,their effect depends on the degree of hepatic cirrhosis.Take ECM generation and deposition as the character of hepatic cirrhosis, when ECM synthesis more than degradation,hepatic cirrhosis happens.The core ring-joint of hepatic cirrhosis is the activation of HSC and HSC converse to MFLC and FC,in addition,reduction of ECM degradaticon,synthesis and degradation not equipollent.The hepatic stellate cells which activated by various kinds of mitosis factors,hyperplasy itself meanwhile secrete plenty kinds of cell factors,and then promote activation of itself further,also induce HSC converse to myofibroblast,myofibroblast multiplies excessively and synthesizes collagen etc as ECM,Which reduces to hepatic cirrhosis.Many kinds of cell factors can cause extracellular matrix synthesis directly.The process was controlled by gene,however,SNPs could influence its express, transcription efficiency and translation,modification,which bring about some influence to people.Hepatic cirrhosis formed when the gene that controls the metabolism of ECM disorders.So far,the candidate genes about liver fibrosis generally accepted only 17 kiands.Professor Guangfu Xu,my advisor,guided by the collaterals disease of traditional Chinese medicine,and body constitution,raises that the pathogenesis of hepatic cirrhosis is 'deficiency of vital energy and collaterals clogging,humid heat in the body' According to this theory,he gives the recipe which called Yi Qi Jie Du Tong Luo Fang.It works well in the clinic.In order to observe the therapeutic effect of Yi Qi Jie Du Tong Luo Fang and study the mechanism of action deeply,we designed this topic.In this topic, we internalized 48patients,who are diagnosed hepatic cirrhosis firmly,to compare the curative effect between prior treatment and post-treatment.The results indicate that the total effective power is 97.92%,and the recipe has good effects on easing symptom,objective sign,and decrease hepatic function, and change the morphous of liver in the brightness mode ultrasonic.In a word,Yi Qi Jie Du Tong Luo Fang works well on easing symptom,objective sign,and decrease hepatic function,and change the morphous of liver in the brightness mode ultrasonic,besides have no adverse reaction and toxic effect, and also is cheap.