| Objective:In order to observe the clinical efficacy of xinglou chengqi decoction treatment of acute ischemic stroke and to discuss its mechanism,we have 60 cases of acute ischemic stroke patients to clinical research.Combined with modern medical research to assess the efficacy recognized test xinglou chengqi decoction clinical efficacy.And determining the level of serum high sensitive C-Reactive Protein(CRP),from Cerebral ischemia-induced inflammatory injury to investigate the mechanism of xinglou chengqi decoction treatment of acute ischemic stroke,with a view to the clinical application to provide a scientific basis.Methods:60 cases of diagnosed with acute ischemic stroke of heat phlegm fu-organ syndrome were randomly divided into two groups,of which 30 cases of treatment group,30 cases of the control group.According to disease give promoting blood circulation for removing blood stasis,improve circulation,and anti-platelet aggregation treatment,the patients of treatment group are given xinglou chengqi decoction(snakegourd fruit 30g,unprocessed rhubarb root and rhizome 10g,stallized sodium sulfate 10g,cry bile arisaema 6g),one dose a day for one week;the patients of the control group are given glycerine enema if necessary,treatment for aweek.Patients with high blood pressure,heart disease, diabetes and other chronic diseases or symptoms of infection can be treated expectant treatment.Recorded pre and post treatment in patients with TCM syndrome score,score of neurological deficits and level of serum high sensitive C-Reactive Protein.All datas were processed using the software package SAS8.0.Results:Compared pre and post treatment,the two groups with TCN syndrome score,score of neurological deficits and the level of serum hs-CRP changed. The treatment group with TCM syndrome score and hs-CRP level were significantly improved,and were superior than control group.By comparison,two groups with clinical symptoms changed significantly,the total effective rate was: treatment group 83.3%,control group 63.3%,the treatment group was significantly higher than that.For score of neurological deficits,both comparisons between pre and post treatment in treatment group and the comparison between treatment group and control group showed,no significant difference(P＞0.05).All 60 cases of patients whose level of serum hs-CRP increased in varying degrees,after different treatment,the level of serum hs-CRP in treatment group significantly decreased compared with pre-treatment,(P＜0.05),there is significant difference;Comparison between the two groups,the treatment group superior to the control group,the differenes had statistical significance(P＜0.05).Compared pre and post treatment,It had a remarkable improvement in wind syndrome,fire syndrome;phlegm syndrome.Comparison of the two groups before and after their treatment,the score of wind syndrome showed significant difference(P＜0.01).Comparison between the two groups,the differenes had no statistical significance(P＞0.05).Compared pre and post treatment,It had a remarkable improvement in fire syndrome showed significant difference(P＜0.01). Comparison between the two groups,the differenes had statistical significance(P＜0.05).For the score of phlegm syndrome,There was significant difference between pre and post treatment in treatment group(P＜0.01),and dissimilarity between in control group(P＜0.05).Comparison between the two groups,the differenes had no statistical significance(P＞0.05).For blood-stasis syndrome,both comparisons between pre and post treatment in two groups and the comparison between treatment group and control group showed no statistical significance(P＞0.05).Qi deficiency syndrome and Yin-deficiency and Yang- hyperactive syndrome has low sample size,so no statistical analysis.Conclusion:In the early period Of acute ischemic stroke,wind,fire,phlegm and blood-stasis is coexist,most heat phlegm fu-organ syndrome,obvious neurological deficits,and the level of serum hs-CRP increased.After xinglou chengqi decoction treatment,the scores of wind syndrome,fire syndrome and phlegm syndrome significantly improved,andcompairdwith theoverall effect of Chinese medicine,the treatment group was higher than control group,serum hs-CRP level rapidly decreased.Clinical symptoms and laboratory indicators of improvement Verifide the clinical efficacy of xinglou chengqi decoction treatment of acute ischemic stroke heat phlegm fu-organ syndrome.Analysis of acute ischemic stroke pathophysiological changesand the key role of inflammatory factors in the cascade reaction of cerebral ischemia, Speculate the mechanism of xinglou chengqi decoction treatment of acute ischemic stroke has a relation with reducing cerebral ischemia delayed neuronal damage, improving microcirculation,in order to play the role of protecting neuronal cells.It may be the clinical efficacy mechanism of xinglou chengqi decoction treatment of acute ischemic stroke. |
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