Tcm Treatment Of Depression Study

Depression is a mood to significant and lasting change as the basic clinical manifestations of mental illness,often accompanied a corresponding change in thinking and behavior.As human disease spectrum of change and the change of life, the incidence of depression increased year by year,a system of one of the most common disease,a serious threat to people's health and life,leading to serious social and economic burden,therefore the treatment of depression as the world's focus.The World Health Organization(WHO) released the information,the existing depression patients around the world about 340 million,the prevalence rate from 3 to 5 percent annually due to mental illness caused by the suicide death toll 1 million and is expected to 2020 depression will become the Following ischemic heart disease after the second-largest burden of disease.The complex causes of depression also can not be identified so far,more consistent view is that the incidence of biological factors constitutes a quality or tendency, psychological and social factors play a role in triggering the media.Western medicine that pathological changes of major depression and central nervous system,immune and neuroendocrine function related to the exact pathogenesis is not clear.At present, a monoamine hypothesis,the hypothesis of neurotransmitter receptors, neuroendocrine function hypothesis,the hypothesis of the immune system abnormalities and other disputes.Currently in clinical commonly used antidepressant drugs,including tricyclic,the Fourth Ring category,neurotransmitter inhibitors, monoamine oxidase inhibitors and other drugs.However,due to side effects, efficacy is not satisfactory,poor compliance,high prices and restricted the clinical application.The depression is a typical biological,psychological,social and other factors caused the disease,can cause human multi-system and multi-level pathological response.Thus a single,clear target of drug therapy will inevitably have some shortcomings and widespread adverse reaction and relapse cases.The multi-level, multi-target Chinese medicine treatment has some potential and advantages.Chinese medicine had an earlier awareness of depression,the related exposition contained in ancient China Medical books.There was no the name of "depression" in TCM,but the etiology detecting,pathogenesis and the treatment of depression were quite rich.TCM classified depression into the emotional disease,and described it as melancholia.In medicine will be mainly in its scope of the,more to the ancient literature of the Melancholia.From "during the" five-yu of the five elements of the natural gas will be the five internal organs of the body changes and the impact of organic combination of gas,through WuZhe Chen Yu doctrine,Danxi six Zhu Yu said,gradually expanded the pathogenesis of Melancholia And treatment of content.Ming Zhang Jingyue,"King Yue book" Melancholia out of the chapter,be systematically explained,for the Treatment of Melancholia later laid the foundation.Inspection history of depression awareness of Chinese medicine,found that each of Melancholia attaches great importance to research and treatment,left for future generations a wealth of dialectical thinking.Modern Chinese medicine clinical study of depression includes etiology detecting,pathogenesis,Treatment Based on the Differential Diagnosis and the using of Chinese medicine.In the clinical treatment of TCM,the connecting of differential diagnosis and disease has made good effect.Clinical ResearchIn this study,out-patient with depression of more than 200 cases,and put into six groups as Stagnation of the Liver-Qi,Stagnation of Phlegm-Fire,Asthenia of both Heart and Spleen,Deficiency of Heart-Blood,Deficiency of Hart and Gallbladder-Qi,Non-harmony of the Hart and Kidney,30 cases each.Depression diagnostic criteria adopted the "China mental disorders classification and diagnostic criteria version 3(CCMD-3)" diagnostic criteria for depression,Chinese dialectical type criterion-referenced SFDA "Chinese medicine clinical research of new drugs guiding principles",Chinese Medicine Authority "Chinese medicine diagnosis Syndrome Evaluation standards" development,Chinese medicine symptoms and signs of reference points of "Chinese medicine clinical research of new drugs guiding principles",a semi-quantitative Points Act.Case inclusion criteria:(1)meet the diagnostic criteria for depression and Western Medicine,the course＞eight weeks(2)TCM for Liver Depression-lag,Tanhuo blues,Xinpi deficiency,the virtual effort,heart and kidney and heart Danqi virtual non-payment of permit Patients(3)Hamilton Depression Scale 17 to inform the scores≥14 points and≤24 points(4)the age of 18 to 65 years old,men and women is not limited(5)was informed and voluntary subjects.Exclusion criteria for cases:(1)pregnancy or breast-feeding women,allergic constitution(2)exclude organic mental disorder,or psychoactive substances and non-addictive substances caused by depression(3)combined liver,kidney,blood system Primary serious diseases, mental patients(4)within the past month to participate in other clinical trials of patients. Case standards for the omissions:(1)The trial began and found the subjects into the cases do not meet standards or meet the exclusion criteria,that is,this should not be a random group of the cases(2)in the group does not record any data(3)Did not test the use of medication(4)the use of banned substances so that the effectiveness and safety of the cases could not be determined.Gave decoction one pharmaceutical twice a day.Xiao yao san for Stagnation of the Liver-Qi,Chai Qin Huanglian Wendan Decoction for Stagnation of Phlegm-Fire,Gui Pi Decoction for Asthenia of both Heart and Spleen,Tian Wang Bu Xin Dan for Deficiency of Heart-Blood,An Shen Ding Zhi Wan for Deficiency of Hart and Gallbladder-Qi,Suan Zao Ren Gao and Jiao Tai Wan for Non-harmony of the Hart and Kidney.TCM Syndrome Clinical criteria used nimodipine index calculated effect.Clinical control:clinical symptoms and signs disappear or disappeared,reducing Syndrome integral≥90%;markedly effective:clinical symptoms and signs improved significantly, reducing Syndrome integral≥70%;effective:clinical symptoms and signs have improved,integral Syndrome Reduce≥30%;invalid:clinical symptoms,no signs of significant improvement,or even increase,decrease Syndrome points less than 30%.The statistical analysis showed that the treatment of depression Zhou Shaohua instructor certification of the cards have a good effect.Clinical control and significant efficiency is about 20 to 50 percent,the total efficiency of 80 percent or more, especially Liver depression and stagnation gas card in the efficiency of control and 50 percent of the Liver depression and stagnation gas card and the card effect Tanhuo blues Is better than two Xinpi Deficiency Syndrome.At the same time,the subjects of the Hamilton Depression Scale Integration there have been noticeable improvements,the treatment of patients by eight weeks,more to improve conditions.ConclusionThe clinical observation Confirmed that the TCM treatment of depression was effective,and my tutor's accurate differential diagnosis.In the circumstances of the depression increasing and the side effects of western medicine,the results of this study show that Chinese medicine has great advantages on depression treatment.The TCM differential diagnosis were not limited to the six-syndromes,the observation of other syndromes and using of herb medicine have to be further studied.