Pcna And Mmp-2 Expression In Endometrial Carcinoma And Its Significance

Objective:To investigate the expression and the clinical significance of PCNA and MMP-2 in endometrial carcinoma as well as their relationship with the clinicopathological factors.Methods:Forty two patients with endometrial cancer, 10 patients with benign proliferative endometrium, 10 patients with endometrium intraepithelial neoplasia were studied their expression of PCNA and MMP-2 by S-P immunohistochemistry.Results:(1) The positive expression rate of PCNA in endometrial carcinoma(EC) was showed statistically higher than that in benign proliferative endometrium(BPE) and in endometrium intraepithelial neoplasia(EIN)(P<0.05), it was proved having statistically relationship with the histopathological grading of the endometrial cancer in our article and the surgical pathologic staging, the depth of the cancer invading uterine myometrium, the lymph node metastasis .(P<0.05).(2) The positive expression rate of MMP-2 in endometrial carcinoma(EC) was showed statistically higher than that in benign proliferative endometrium(BPE) and in endometrium intraepithelial neoplasia(EIN)(P<0.05), it was proved having statistically positiverelationship with the histopathological grading of the endometial cancer, the surgicalpathologic staging, the depth of the cancer invading uterine myometrium, the lymph node metastasis (P<0.05). (3) The positive expression rate between PCNA and MMP-2 in endometrial carcinoma was showed statistically positive correlation(P<0.05).Conclusion:(1) In our article, PCNA was showed expression in endometrial carcinoma. The expression of PCNA was correlated with the surgical pathologic staging, the depth of the cancer invading uterine myometrium, the lymph node metastasis . The expression of PCNA was proved being correlated with the progression and metastasis of the endometrial carcinoma. (2) MMP-2 was showed expression in endometrial carcinoma.The expression of MMP-2 was correlated with the histopathological grading, the surgical pathologic staging, the depth of the cancer invading uterine myometrium, the lymph node metastasis. The expression of MMP-2 was proved being correlated with the progression and metastasis of the endometrial carcinoma.(3) The expression of PCNA and MMP-2 in endometrial carcinoma was showed statistically positive correlation. It was supposed that there would be some interaction between PCNA and MMP-2 in the progression and metastasis of the endometrial carcinoma.(4) Detecting the expression level of PCNA connect to MMP-2 might be useful for the prognosticator of the malignance extent, metastasis and prognosis of the endometrial carcinoma. Our study preferd that PCNA and MMP-2 were useful tumor markers to evaluatethe degree...