| Objective Purpose research reorganization person inside suppress a vegetable(endostatin) the influence of the IL-1, IL-6 and Leptin expression level in the arthritis(AA) serum to the big rat to inquiry into endostatin the treatment function of the arthritis to the big rat adjuvant arthritis.Method The method passes to inject complete establishment rheumatism of the adjuvant arthritis the animal model(AA) of the arthritis inside skin to the big rat right empress foot department.At with the result that burning after d 10, the big rat appears after the hair arthritis.Start in the experiment set the rat subcutaneous injection with big AA suppressing a plain 2.5 mg·kg-1, continuous 7 ds. Use to put to don't need the expression level of the IL-1, IL-6 and the Leptin in the rat serum with big AA of the method(RIA) measurement experiment set while keeping to d24 rightnesses of big rats foots claws to swell a degree to repress to show .significance.Result experiment set the level IL-1 in the rat serum with big AA is low in the matched control, the levels IL-6s are low in the matched control, the Leptin level is low in the matched control, and Leptin expression level and IL-1, IL-6 in the serum present to show significant direct correlation just related.Conclusion Reorganize a person inside suppress a vegetable an arthritis to the big rat adjuvant arthritis of after the inflammation disease suppress obviously.The creation uses, inside suppress a plain 2.5 mg·kg-1 The IL-1, IL-6, Leptin in the rightness kg-1 rat serum with big AA of the expression level repressed a function obviously, and Leptin expression level and IL-1, IL-6 in the serum present to show significant direct correlation just related. |
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