Clinical Observations, Around The Traditional Chinese Medicine To Combat Chemotherapy Drugs Oxaliplatin Neurotoxicity

The paper consists of two parts: a literature review and a clinical research.The literature review is about the advances in the treatment of peripheral neurotoxicity caused by Oxaliplatin in recent years. It includes clinical symptoms, mechanisms and the advances in management of Oxaliplatin-induced neurotoxicity with TCM and Western Medicine. Aggregate analysis, peripheral neurotoxicity caused by Oxaliplatin is its main side effect and influence the patients'quality of life. According to the clinical observation, it proved that TCM is efficient in prevention and treatment of Oxaliplatin-induced neurotoxicity.The second part is a clinical study. Objective: To investigate the effects of TCM in the treatment of peripheral neurotoxicity caused by Oxaliplatin. Methods: All the patients were diagnosed from gastric carcinoma or colorectal carcinoma.The patients were divided into two groups randomly. Every patients received two cycles of Oxaliplatin-based chemotherapy. The patients in treatment group received both TCM and chemotherapy. The patients in control group received chemotherapy alone. The clinical symptoms of neurotoxicity were observed, and the level of NGF before and after chemotherapy were measured. Results: 73 patients were studied. The incidence rate of peripheral neurotoxicity are 82.2% (60/73) in treatment group and 87.7% (64/73) in control group. The difference between two groups is significant (P<0.05). In 14 patients the level of NGF were measured. The descent of NGF is less serious in treatment group than that in control group after chemotherapy. Conclusion: TCM is effective in prevention and treatment peripheral neurotoxicity caused by Oxaliplatin, which is worth of a further research in oncological clinic.