| OBJIECTThis thesis aims to provide theoretical basis for the study of the new clinical medicine by observing the curative effects of the Addition and Subtraction Treatment of chronic superficial gastritis (CSG) by decoction HUO PU XIA LING TANG and discussing its possible functional mechanism.METHODS100 patients whose diseases are diagnosed as CSG (damp-heat in spleen and stomach) after gastroscopic and pathological examinations in the digestive medical department of Hubei Traditional Chinese Medical Hospital are selected as subjects and randomly divided into two equal groups: the treatment group of CCTWM and the control group of simple western medicine. The two groups of patients are comparable since they have no significant differences before treatments in aspects of sex, age, course of disease, main traditional Chinese medical symptom, gastroscopic examination, pathological test, and Hp infection (P>0. 05 )..In the two groups, those who show acrid regurgitation are treated by omeprazole enteric-coated tablets (swallow, 20mg every time and twice a day) . Those who have acid suppression, delayed gastric emptying and duodenal reflux are treated by Motilium tablets to promote gastric dynamics (swallow, 10mg every time and three times a day ) . Those who have hyperemia gastric mucosa and severe erosion are treated by sucralfate suspension to protect gastric mucosa (Sucralfate, swallow, 5ml every time and three times a day) . Those with severe erosion of gastric mucosa in the control group are treated by omeprazole enteric-coated tablets (swallow, 20mg every time and twice a day), clarithromycin tablets (swallow, 250mg every time and twice a day) and amoxicillin tablets (swallow, 1.0g every time and twice a day ). The treatment group is treated with decoction HUO PU XIA LING TANG, the composition of which includes agastache rugosa, magnolia officianlis, pinellia ternate, poria cocos, Amoni compacti, coix seed, almond, coptis chinensis, atractylodes lancea, atractylodes, eupatorium fortune and taraxacum herb. Take these herbal decoctions with luke warm water, 200ml every time and twice a day.One treatment period is 4 weeks for each groups. The curative effects will be judged after the patients have taken the medicine for one period. What need observing include the total effective rate of patients in the two groups, main CTM symptoms and the improvements of the integrals and the results of gastroscopic and pathological examinations and Hp negative-conversion.RESULTSAfter the treatment, the total curative effect of the treatment group is 92.0% and the control group 78.0%. The statistic analysis reveals that when P<0. 05, it has significant differences. The total effective rate of the treament group in the Chinese medical symptom is 96. 0% and the control group 78.0%. Statistics reveals that when P< 0. 05, it has significant differences. Traditional Chinese medicine syndrome integrals of the treatment group and the improvement of the main and minor syndrome integrals are better than that of the control group ( P < 0. 05 ) . The effective rate of the treatment group in gastroscopic examinations and pathological changes are 76.0% and 82.0% respectively while the control group 58.0% and 62.0%. The improvement of the treatment group is obviously better than that of the control group (P<0. 05 ) , but the rate of Hp negative-conversion is 45.4% while the control group 25.8%. The statistic analysis shows that when P > 0. 05, the two groups have no significant differences in avoiding Hp infection.CONCLUSIONBased on the traditional methods of heat-clearing and damp-drying, invigorating spleen and stomach and regulating Qi and analgesia with a combination of the theories of modern medical science such as Hp inflection, gastrointestinal dysfunction and maladjustment of the mechanisms of gastric mucosal protection, this thesis decoction HUO PU XIA LING TANG usually uses western medicine to treat the disease. The result reveals that CCTWM is very effective in treating CSG, and the effect is better than that of the control group which uses western medicine only. decoction HUO PU XIA LING TANG possibly have such functions as antiinflammation and analgesia, increase body's immunity, protect gastric mucosa, enhance gastrointestinal impetus, anti Hp infection and antitumor. In treating the disease with western medicine, it has a synergetic enchanting effect. It shows that the composing prescriptions of decoction HUO PU XIA LING TANG is suitable for the clinical reality. They do have some curative effects in treating CSG (damp-heat in spleen and stomach)and are worth further study and recommending. |
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