The Salsola The Medicinal Quality Standards And Its Capsule Preparation Process

Objective: Common Russianthistle Herb is good for decreasingpressure, but there is no quality control standard about it both in nationalpharmacy code and local standards and there are seldom reports about itsproduction. So, it is necessary to carry out researching on CommonRussianthistle Herb. The author conducted research on its pharmaceuticalquality control standard and its capsule production craft, and alsodiscussed the quality control of the Common Russianthistle Herb capsule.Method: The study of the quality control standard takes the methodsof character identification, microscopical identification, chemicalidentification and takes the alkaloid deposition reaction as its target,probing the method of thin-layer chromatographic scanning; theproduction craft of Common Russianthistle Herb capsule takes reinecksalt sediment of Common Russianthistle Herb general alkaloid as thetarget, first examining the effects comparison of ethanol circumfluenceand water extraction; when using water to extract medicinal materials,there are three factors with great influence on the extraction results,i.e.the quantity of water (A), the time of decoction(B),the times ofdecoction(C);the design for these factors are as following: the quantity ofwater is 6,8,10 times (A₁,A₂,A₃)as medicinal materials weight, thetime of decoction is0.5,1.0,1.5h (B₁,B₂,B₃), the times of decoctionis1,2,3 times(C₁,C₂,C₃), the experiment takes the design ofL₉(3⁴ )Orthogonal Test, to find out the optimal extraction condition;when carrying out the comparison experiment of the alkaloid sediment,we have to takes the same amount of water extract from CommonRussianthistle Herb, with the same volume of solution, making pH is 2,and then drip in overdoes of reineck salt, to ensure ample sediment, wecan take methods such as decoction by water,comminute,make granule tomake capsules; In the study of quality control of Common Russianthistle Herb capsules, we will takes the method of thin-layer chromatographicscanning to make qualitative examination on the Common RussianthistleHerb capsules, comparison sample liquor preparation(takes CommonRussianthistle Herb medicinal materials powder 0.1g, adding methylalcohol 10ml, calefaction circumfluence 30min, strain through, filtrate byway of comparison sample liquor), takes comparison liquor andsupplying test sample liquor accoording to lamella chromatogrammethod(2005 pharmacopoeia appendix VIB) examination, takes twokinds of liquor 10μl each, leave each other pointing at same silica gel Glamella board, takes acetic acid and acetic ester-丁ketone-armouracid-water(10:6:1:1) as unwrap dose, puts ammonia evaporationbeforehand saturated expandedness in the vat.unwrapping, taking out,cooling and drying.puts them below the violet light lamp(365nm) topostmortem, supplying sample and comparison sample chromatogramcorresponding site,apparents same fluorescence spot.according tomensurating to make capsule install quantity diversity,grain alcohollixiviate matters in the 2005 edition pharmacopoeia, makes out threetimes reineck salt deposition experiment,then takes average cost80ï¼…,asreineck salt deposition lower limit examine.Result: Common Russianthistle Herb medicinal materials powderphysical and chemical discriminated deposition reaction producesfloccule deposition; thin-layer chromatographic discrimination appearstwo same colour fluorescence spot. water extraction method is the bestway in the arts and crafts of Common Russianthistle Herb capsulepreparation, water extraction method's best condition is adding waterquantity 10 times,decoction every time 1.5h, before experiment,decoction 3 times; pick-up alkaloid deposition rate is 2ï¼…in the optimalcondition (100g Common Russianthistle Herb medicinal materials can getabout 2g deposition).uses Common Russianthistle Herb medicinalmaterials as comparison sample and determine the nature discriminationof Common Russianthistle Herb capsule,takes the thin-layer chromatographic method to appear same colour fluorescence spot.loading capacity diversity control about 10ï¼…; ethanol exactionmensuration can not below 25ï¼…. reineck salt deposition quantity lowerlimit (each 1.5g Common Russianthistle Herb water extraction fromCommon Russianthistle Herb gets deposition is about 0.2g).Conclusion: Common Russianthistle Herb medicinal materialsmostly comprises of alkaloid, thereinto Common Russianthistle Herbalkali A is quaternary ammonium base, but reineck salt is quaternaryammonium base alkaloid expert precipitator, it's more trust to measureextraction effect by deposition capacity and the method is moresimple,operation is easier than others.water extraction rate is higherthan other matters ,and availability component quantity is much more,according to water extraction method making arts and crafts of CommonRussianthistle Herb capsule is scientific, this method is simple andreasonable,it is good for making Common Russianthistle Herb topreparate stabilizated quality, and is easy to carry and take Chinesetraditional medicine preparation. This task is based on inside andoutside nations reaserch about Common Russianthistle Herbmorphologic, pharmacognosy, chemistry component,pharmacology. Firstâ… bring forward alkaloid reineck salt deposition quantity as reviewtarget, reviewing distill method and handle Orthogonal Test methoddesign, find out optimal preparation crafts,and fish out the optimalcondition of thin-layer chromatographic discrimination under theCommon Russianthistle Herb finished capsule product control, thenprovide some giests of discrimination, exploitation and utilization ofCommon Russianthistle Herb.