Studies On Chemical Constituents Of American Ginseng Fruit

Fifteen compounds were isolated from the fruits of Panax quinquefolium L. cultivated in China on the basis of the widespread investigation of the resource and literatures with such techniques as D101 macroporous absorption resin (MAR), chromatography, and octadecylsilane (ODS) ect.. Fourteen compounds were identified according to physico-chemical properties and spectral data. Their structures were identified as: 20(R)-protopanaxadiol(I), 24(R)-Ocotillol ( II ), 20(S)-panaxadiol (â…¢), 20(S)-protopanaxatriol (â…£),β-sitosterol (V), daucosterine (â…¥), 20(S)-ginsenoside-Rh2 (â…¦), ginsenoside-Rg1 (â…§), 20(R)-ginsenoside-Rg3 (â…¨) , pseudoginsenoside-F₁₁(â…©), ginsenoside-Rd (â…ª), ginsenoside-Rc (â…«), ginsenoside-Rb1 (â…©â…¢), ginsenoside-Rb3 (â…©â…£). As a result, compoundsâ… ,â…¡,â…¢were isolated from the plant for the first time.The metabolism of ginsenoside-Rd in rats after ip 250 mL/kg and po 400mL/kg respectively, was studied in the paper. In the pilot study, thin-layer chromatograph (TLC) and high performance chromatography (HPLC) were used to assay the samples of the rats' urine and feces. The results showed that ginsenoside-Rd had 5 main metabolites, which were ginsenoside-Rg3, F2, Rh2, Coumpound K (C-K) and 20(S)-propopanaxadiol.