Longevity Oral Liquid Secondary Development

Qibaomeiran oral liquid consists of Polygonum muliflorum, Lyciumbarbarum,Angelica sinensis, Poria cocos, Psoralea corylifolia, Eclipta prostrata,etc. Itis applied mainly to treat Antisenality etc.Modern and advanced technology and method were used in the article to studyon the Qibaolneiran oral liquid ,and to make a new development,in order to raise thetechnical content and compete power of products,and the curative effects.Theprocessed by different methods,the preparation technology and quality standard werestudied in the article.The efficacy in the main medicine Polygonum muliflorum have relationshipwith processe. Different methods of processing Radix Polygonum Muhiflorum and the changeof chemicar components 2, 3, 5, 4'-stilbene glucoside and anthraquinone was investigated andthe best process method technology is the ninth steams and the ninth suns.The optimization and compare experiment were applied to choice the best extracttechnology. The optimum mixture extraction process is as follows: Polygonummuliflorum, Psoralea corylifolia and Cuscusta chinensis plus 60％alcohol extractingthree times,adding 6 times amount of alcohol into Chinese medical material,andextracting for 90 mins each time.The others water decocte,the result asfollows:waters extracting twice,adding 10 times amount of water into Chinesemedical mateial,and extracting for 120 mins each.The mixture liquid was concentrated to 7:1(material decoction volume).Weselect absorbing clarification method to refine.After refinement active componentretaining clarication rate is more the 70％. Model craft indicates that after joining0.2％sodiums with sour benzoate, 0.2％sodium cyclamate,the oral liquid has goodstability.The feeling in the mouth is good.Adapt TLC to identify Polygonum muliflorum,Lyciurn barbarum,Angelicasinensis, Adapt HPLC to examine 2, 3, 5, 4'-stilbene glucosidecontent in sample,carry metrology review and establish quality controlled standard, average recovery is 98.98％,RSD is 0.86％.The method was exactly,reliable and steady.Through thethermostatic accelerated test,the oral liquid period of validity is steady.The new technological process was based on the pharmacodynamics,andcombined with reports of literature.The results of primary pharmacodynamics showthat,new technological products were better than original technological products ondelaying seniling of aged moble mice effects.