| Objective: The aim of this study was to examine the expression of Ki67 and Fas in Esophageal Squamous Cell Carcinoma(ESCC) and examine its correlation with clinicopathological features.Methods: The expression of Ki67 and Fas was detected by immunohistochemical SP method in 46 cases of ESCC and 14 cases of normal esophageal epithelium surrounding the tissues of carcinomas as contrast group.Results: The expression level of Fas in 56.5% in ESCC and 86.7% in benign tissue surrouding carcinomas. There was a significantly difference of the expression of Fas between ESCC and normal esophageal epithelium (p＜0.05).The expression of Fas was significantly related with the histopathological types(p＜0.05),the expression of Fas in Well differentiated carcinoma is much higher than in poorly differentiated carcinoma. The expression of Fas was not associated with the TNM clinical stage,the T grade,the lymph node metastasis,the nationality(Chinese and Korean in Yanbian),the age and the sex(p＞0.05). The Ki67 was not expressed in normal esophageal epithelium and was localized in the nucleus in ESCC(82.6%).There was a significantly difference of the expression of Ki67 between ESCC and normal esophageal epithelium (p＜0.01).The expression of Ki67 was not related to the classification of pathology, the TNM clinical stage, the T grade, the lymph node metastasis, the nationality(Chinese and Korean in Yanbian),the age and the sex(p＞0.05). There was negative correlation existing between Ki67 and Fas protein expression in ESCC.Conclusions: The expression of Fas protein was decreased with the increase of the degradation of the pathology, indicating its inactivation in the process of ESCC. The high expression of Ki67 in ESCC and its loss of expression in normal esophageal epithelium indicated its role in the formation and development of ESCC. So both of them could probably provide some useful ways on early diagnosis, therapy and prognostic analysis for ESCC. |
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