| Dioscorea nipponica Makino is a plant of the family Dioscorea, which is distributed in Inner Mongolia, Heilongjiang, Jilin, Liaoning and other provinces in China. The plant is not only a main resource to medicines for cardiovascular diseases, for example DP and DioscorninTablets, but also one of the useful sources of diosgenin, a widely used raw material for the production of steroid and contraceptive. It has been used for the treatment of many ailments including coronary heart diseases, atherosclerosis, hyperlipemia, inflammation, tumours, etc. Its effective parts are the total sapogenins of Dioscorea nipponica Makino.The previous studies mainly focus on the saponins and nonpolarity chemical composition, yet other water-soluble constituents were not investigated and method is water decoction to take in traditional. One of the active components could be the water-soluble constituents. So the topic principally studied on the water-soluble constituents of Dioscorea nipponica Mak.. The fourteen compounds were isolated and their structures were identified on the basis of analysis of IR, UV, NMR, MS data and physico-chemical constants as following: (+)syringaresinol-4-0-β-D-glucopyranoside (1), benzyl l-O-β-D-glucopyranoside (2), cyclo-(Leu-Tyr) (3), Phenylethyl 1-O-β-D-glucopyranoside (4), 4-hydroxy-2,6-dimethoxyphenyl-β-D-glucopyranoside (5), embran (6), cyclo-(Ser-Tyr) (7), 2-(4-hydroxyphenyl)ethyl-β-D-glucopyranoside (8), pyrocatechol 1-O-β-D-glucopyranoside (9), pyrocatechol 1-O-α-D-glucopyranoside (10), benzoic acid (11), pseudoprotodioscin (12), methylprotodioscin (13), protodioscin (14).The fourteen compounds were getten from Diosorea, and the compounds (1-11) were obtained from Diosorea for the first time, other three compounds (12-14) belongs to water-soluble saponin. |
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