N-aryl-substituted Isothiourea Class H ~ + / K ~ +-atpase Inhibitor Of The Synthesis And Activity Of Research

H⁺/K⁺-ATPase inhibitor has become novel type of antiulcer drug with inhibition of gastric acid secretion after the apperance of histamine H₂-receptor antagonist, In order to find new H⁺/K⁺-ATPase inhibitors, a series of new N-arylisothiourea derivatives were synthesized and their structures were indentified by ¹H-NMR, ¹³C-NMR, and MS.The method of affusing the dissociate stomach of the big rat was used to study the changing of the gastric acid secretion affected by the target compounds.The result showed that eleven of the target compounds have comparable or strong gastric acid inhibitory activities with the positive control magnesium pantoprazole .Especially, compound BTU-11 gave the most powerful activity which was 1.5 times higher than that of the control.Using their assay results we studied the QSAR of the N-arylisothioureas by CoMFA computation.And we got the regular how the steric factor and electrostatic factor effect on the bioactivity.And we also predicted the model structure which will have more powerful bioactivity based on the regular .This regular will benefit the work of modifying the molecular to find the better H⁺/K⁺-ATPase inhibitors in the future.