Synthesis And Biological Activity Of Resveratrol Analogues

Resveratrol (3,4 ,5-trihydroxy-trans-stibene), is a phytozlexin found in grapes and certain other plants. The compound exhibits a variety of useful bioactivities including antiinflammatory, anticarcinogenic, antiplatelet aggregation, antioxidative and antibacterial activities. In this thesis, resveratrol as a lead compound, 28 its analogues have been designed and synthesized, including 10 intermediates and 18 target compounds. Total 28 compounds are divided into four different categories: methoxy -substituted, hydroxyl-substituted, acetic acid (acetic acid ethyl ester), Mannich base of hydroxyl- and dihydroxyl-analogues. 18 Target compounds were not reported in the literatures and their structures were confirmed by ~1H-NMR.Some target compounds and intermediates were tested by antiplatelet aggregative experiments. According to screening results, there are no any activity against platelet aggregation. Antiinflammatory activity test showed that all compounds have some activity on xylene-induced ear edema. Especially, RS8, RS10, RS18, RS22, RS27 at the dose of 200mg/kg were a little less potent than Ibuprofen at the same dose.Other activity tests are under investigation now.