Complex Xin Tang Protective Effect On Acute Myocardial Ischemia And Left Ventricular Diastolic Function

Objective:To observe Fuxintang' s influence on model of rat' s myocardial ischemia. Methods:sixty wistar rats that the quantity of the male was equivalent to that of the female were used and six groups were divided randomly. Each guoup had ten rats. Control group:every rat was perfussed with 0. 9% NACL solution . Model group: every rat was perfussed with 0. 9% NACL solution . Di' aoxinxuekang(DAXXK) group:every rat was perfussed with DAXXK that was equal to the quantity of man' s equivalent dosage (0. 12g/kg/d) . Fuxintang(FXT) high group:every rat was perfussed with FXT that was as six times as the quantity of man' s equivalent dosage (81 g/kg/d) . FXT middle group:every rat was perfussed with FXT that was as three times as the quantity of man' s equivalent dosage (40. 5g/kg/d) . FXT low group:every rat was perfussed with FXT that was equal to the quantity of man' s equivalent dosage (13. 5g/kg/d) .Bid , keeping 7 days. At 8th day, the rats of every rats (except the rats of the control group) were injected with pituitrin that could establish model of acute myocardial ischemia of rats, observing the change of ECG LDH CK - dp/dtmax LVEDP. Result: Every group of FXT can effectively prevent ST and T of ECG of rat' s acute myocardial ischemia from changing, and can reduce LDH CK content of myocardial tissue of the rats. In addication, FXT can decrease left ventricular end-diastolic pressure (LVEDP) , while enhance maxmum rate of left ventricular pressure descend (-dp/dtmax) . Conclusions:FXT has inhibitory function on myocardial ischemia .FXT is the valuable medicine that can treat and prevent myocardial ischemia, improve the myocardial relaxation of left ventricular.