Brugada Syndrome Scn5a Mutation Detection And Icd Treatment

[Objective] To detect the gene mutation of Gene SCN5A in 7 patients with Brugada syndrome and study the molecular genetic character of this disease.[Methods] Genomic DNA was extracted from peripheral blood of all the 7 patients diagnosed as Brugada syndrome and 41 pairs of PCR primers were designed to amplify all the 28 exons of SCN5A.DNA sequencing and analysis was followed.[Results] No novel mutation was found in Gene SCN5A.[Conclusion] There could be some other genes that contribute to Brugada syndrome except SCN5A.