Molybdenum Oxygen Transfer Biomimetic Synthesis And Structural Properties Of The Activity Factor

Molybdenum is an essential trace element that plays important roles in the global cycles of nitrate, sulfur, and phosphor. It takes two forms when participated in the element metabolism, one is as inorganic salt and composed with nutrition, the other is as the cofacter of molybdeumenzy and takes part in many biochemistry reaction. Since last century 50 s the research shows that there is another kind of enzyme containing molybdenum except for nitrogen enzyme, which include xanthenes oxidase, nitrate reductase , Sulfite Oxidase and Aldehyde Oxidoreductase et al. Those molybdeumenzy had important influence upon the metabolism of carbohydrate, fat, protein, sulfamino acid, nucleic acid (DNA and RNA), and iron in iron albumen.Chiral octahedral molybdenum-containing complexes are active cofactor of biomemic molybdeumenzy. Being similar complex compare with cis-platinum, there are provided with incising and identifying DNA and anticancer activity. So biomemic synthesis and biochemical mechanism study of active cofactor of molybdeumenzy attracted considerable attention. 1 Four different complexes were synthesized by the reaction of tetra-butyl ammonium β-octamolybdate with catechol in the mixed solvent of CH₃OH , CH₃CN, with NH₂CH₂CH₂NH₂, NH₂CH₂CHNH₂CH₃, and NH₂CH₂CH₂CH₂NH₂ added differently, and structurally characterized by x-ray diffraction. The crystal structure results show that the mononuclear anionic unit of the four complexes displayed the same cis-dioxo fashion with pseudo-octahedral [MoO₆] coordination geometry. But the four complexes have different crystal figure, stability and anti-cancer activity. Those complexes show the similar EPR signals with xanthenes oxidase in milk and semblable UV-VIS signals with xanthenes dehydrogenase in chicken liver. And some of the complexes have excellent anticancer activity.2 catechol was chosen to react with Na₂MoO₄ in the mixed solvent of CH₃OH, CH₃CN, with NH₂CH₂CH₂NH₂, NH₂CH₂CHNH₂CH₃ added differently, and three different...