The Clinical Significance Of The Diabetic Patients With Lower Limb Imt And Vascular Inflammatory Factor

Objective- to study the crural arterial IMT (intima-media thickness) of thepatients with type 2 diabetes and the contribution of a range of vascular risk factors to their IMT.Research design and methods-IMT were determined using ultrasound B-mode imaging in 104 subjects with diabetes and 50 nondiabetic subjects. And their major cardiovascular risk factors, including plasma lipids , WBC count, plasma high-sensitive C-reactive protein (hs-CRP)and fibrinogen(Fg), were measured respectively by enzymatic assays and other methods. Their clinical data (eg. blood pressure and diabetic period and age et al) were recorded too.Results- Patients' CFA (common femoral artery) IMT and POA (popliteal artery) IMTwere correlated with their CCA (common carotid artery) IMT. And diabetic patients had higher IMT of CCA and CFA and POA than normal nondiabetic subjects , especially in CFA and POA(CCA IMT 0. 76±0. 18mm VS 0. 5 + 0. 15mm, p=0. 000; CFA IMT 0. 87 + 0. 56 mmVS0.49 + 0.13 mm, p= 0.003; POA IMT 0. 87 + 0. 59 mm VS 0. 45 + 0. 09mm, p=0.003). IMT were correlated with Fg and WBC and hs-CRP (CFA and Fg, r=0.216, p=0.007; CFA and WBC r=0.210, p=0. 033 ; CFA and hs-CRP r=0.190, p=0. 045. POA and Fg,r=0. 174, p=0. 031 ; POA and WBC r=0.235p=0.003; POA and hs-CRP r=0. 220, p=0. 048) .The presences of diabetic foot are positively correlated with patient' s age and duration of DM and the marks of lower-grade inflammation (p<0.05).Conclusions-Diabetic patient' s crurual arterial disease could be found earlyby IMT measurement with ultrasound. And patient' s age and diabetic period and lower-grade inflammation of blood vessel may be contributed to their IMT.It is efficient to diagnose DMF to using CFA IMT≥1. 0mm. It is more efficient to diagnose DMF to using POA IMT≥1.0mm when measuring only one artery. It is the most efficient to diagnose DMF to using CCA IMT≥0.8mm and CFA and POA IMT samely≥1.0mm.