Theory Of Bushentongluo Treatment Of Rheumatoid Arthritis, Clinical And Experimental Research

1 Theory research: Rheumatoid arthritis(RA) is a common chronic inflammatory disorder involving the synovial membranes of multiple joints.Although rheumatoid arthritis is thought of an autoimmune disease,its aetiology is unknown.And it is probably the most common source of disability.It needs further exploration of these influences urgently because current therapies frequently fail to interrupt the established disease process. According to the theory of Tranditional Chinese Medicine(TCM),summing up TCM's recognize on RA , advancing TCM's pathological mechanism ,therapeutic principle and method. To sum up the tutor's experience on the treatement of RA and draft the therapeutic method and prescription ─Bushentongluo fang(BSF) on RA based on "kidney". TCM's pathotogic mechanism of RA was deficiency of the kidney.Kidney deficiency played an important role in the invasion of RA,and kidney deficiency has close contact with the Hypothalamus-Pituitary-Adrenal(HPA) axis,and HPA axis has close contact with RA,so we can suppose that supplying kidney can adjust the HPA axis ,and therapy RA. 2 Clinical research 60 cases of RA were divided into two groups.The treatment group(n=30) was treated with BSF.The control group (n=30)was treated with tripterygium wilfoudii polycoside tablet(TPT).Two groups were treated for one course all.The results of clinical research:The effect of BSF was similar to TPT in the total effective rate,improving the joint symptoms et al.But the BSF was superior to TPT in improving general symptoms of the patients with RA,regulating the balance of HPA axis. 3 Experimental research Animal models of RA especially adjuvant arthritis(AA) in rats has much character similar to human RA in pathological mechanism ,clinical representation and so on. The model is more ideal in investigating RA and selecting drugs of anti-inflammation and immunity.To discuss the pathological mechanism and the relation between animal models of RA and clinic will be important not only to research RA in pathology,physiology,nervous-endocrine-immunity and so on, but also to find out safety and effective drugs of treatment RA. TCM's pathotogic mechanism of RA was deficiency of the kidney,so we use Hydroxy-carbamide Tablets to make the model of kidney deficiency of yang-qi.So we have the model of kidney deficiency in AA. The results of experimental research:The swelling degree of posterior metatarsus in BSF and TPT group obviously lowered after treatment.The arthritis index (AI)of BSF and TPT treated group was markedly decreased after treatment,and the 12g/kg group is more obviously than the 4g/kg group.The increment of rat body weight in BSF treated group wasn't significantly different from that of normal control group,but was significantly different from that of model control group.The 17-OHCS and Cort of the 12 g/kg BSF group were higher than the 4g/kg BSF group and the TPT group.The BSF group can restraining the inflammation and the hyperplasia of synovial membranes. 4 In conclusion,the results indicated that BSF could take a good effect in the treatment of RA,from the thought of supply kidney and adjust the HPA axis.The research also accomplish the exploration on the theoretical study and animal experiment based on the TCM theory. It suggests that in regulating on the endocrine system by the TCM herbs can improve the immune system and reduce the damage of RA ,and it is a useful method to treat the RA in the future.