The Electromagnetic Control Thermal Magnetic Liposome Drug Release Of The Preliminary Study

Thermosensitive magnetoliposomes are the kind of liposomes prepared with thermosensitive liposomes, magnetic materials and drugs. It is strongly suggested that thermosensitive magnetoliposomes can provide many advantages at the same time in treating cancer, that is, selective hyperthermia, magnetic targeted drug delivery systems and etc. With its great promise and potentiality in the future, scholars in home and abroad are managing to make the thermosensitive magnetoliposomes feasible in the medical practice.To investigate the electromagnetic parameters of thermosensitive magnetoliposomes in the whole electromagnetic waves frequencies band, studying super fine Fe3O4 nanoparticles is necessary and important. In this postgraduate thesis, several groups of Fe3O4 nanoparticles samples are acquired by the means of chemical co-precipitation changing the reacting temperature, pH and concentration. The component of Fe3O4 is verified with the X-ray diffraction spectra and the Specific Saturation Magnetization of each sample is characterized with the magnetic balance. Moreover, the method of preparing Fe3O4 magnetic fluid taking the PEG-4000 and polyacrylic acid (PAA) as dispersant is explored. The factors that influence the magnetic positioning include the magnetic properties of magnetic drug particles, hemodynamic forces, the magnetic filed gradients and variable tissue characteristics. The magnetic responsiveness of magnetic drug particles, the blood properties and the hemodynamic forces are analyzed in detail. The magnetic agglomeration force is considered when the magnetic drug particles are in high concentrations.The various electromagnetic frequencies applied in medical practice are listed and their spreading characteristics in human being are concluded. The principles of drug release of thermosensitive magnetoliposomes controlled by electromagnetic waves are discussed in the view of electromagnetics. The mathematical models of controlled drug release of thermosensitive magnetoliposomes are built.