Pulse Through The Side Of Early Intervention On High-sugar High-fat High-cholesterol Diet Dm Rat Vascular Protection

Objective To investigate the preventive effect of Maitongfang on the early stage of diabetic arterial disease, mainly the changes of plasma thromboxane A2 (TXA2) and plasma prostacyclin 2 (PGI2) Methods The SD rats were randomized into three groups, Model control, Matongfang, Cilostazol respectively, and fed with high-sugar, high-fat and high-cholesterol feeding stuff and then induced by Alloxan intraperitoneally to be diabetic rat models. Maitongfang and cilostazol were used at the beginning of the trail. Normal control group was also established. The effect of different medicines on the following parameters were detected by radioimmunoassay, biochemistry method, Histomorphometry, etc. which were level of insulin, TC, TG, HDL-C, Lp (a) , ET, NO, TXB2, 6-Keto-PGF1a, tectology of femoral artery, changes in general condition and blood glucose as well. Results The abnormality of most of the parameters stated above were shown in DM rats, as well as the pathologic changes of femoral artery. While Maitongfang demonstrates the action of improving the general condition, adjusting the metabolism of blood glucose and blood lipid, correcting the dysfunction of endothelium, improving the function of platelet aggregation. The comprehensive curative effect of Maitongfang is superior to that of Cilostazol group. Conclusion Through the regulating action of many pathways and links which presented as alleviating or eliminating damnification on Tunica intima of artery by above factors, Maitongfang contributes to the prevention of diabetic arterial disease in the early stage by regulating the function of platelet.