| OBJECTIVE:To study the antagonism of L-tetrahydropalmatine (L-THP) against bromocriptine(Bro)-inhibition at the prolactin (PRL) level in order to prove that L-THP is an antagonist of dopamine D2 receptors. METHODS:The agulactosis model was established by Bro(O.5mg.kg-1d-1,sc).The antagonism of L-THP(6 & 18 mg. kg-1d-1,ip) was evaluated by detecting prolactin level in serum , weight growing of newly-borne rats , and histology changes of maninary gland. RESULTS:Bro (0. 5 mg. kg-1d-1sc) reduced the PRL and caused a dysplasia of maninary gland in lactational rats. The weight growing of newly-borne rats was retarded. L-Tetrahydropalmatine 6 & 18 mg. kg1dip remarkably improved prolactin level of lactational rats antagonized by Bro, promoted weight of newly-borne rats, and made the development of tnanuuary gland in lactational rats to be good. CONCLUSION:L-tetrahydropalmatine(L-THP) was an antagonist of dopwnine D2 receptors. |
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