Ph Chromosome Bcr/ab1 Fusion Gene Detection In Cml, The Clinical Significance

Objective: To investigate the value of the detection of Ph chromosome and bcr/abl fusion gene in the diagnosis, treatment and prognosis in CML. Methods: Forty ne patients were studied, twenty with Ph chromosome positive and bcr/abl fusion gene positive chronic phase chronic myeloid leukemia were divided into two groups at random. One were treated with 1-lu and Bestatin and another were treated with llu and IFN?a. Marrow samples from them were analyzed by G banding technique and RTestCR method every three months. Results: 1-. Ph chromosome and bcr/abl fusion gene were both positive in 36 and Ph bcr/abl+ in 5. b.a2 type was detected in 29 and b2a2 type was deteted in 12; 2.. In IFN group, all got CUR. Among them, one got complete cytogerietic remission (CGR), two got partial genetic remission (PGR) and four got MiGR;3, All cases got CuR in Bestatin group, in which 6 got minor genetic remission (MiGR) ; 4.. None got molecular biology response in both groups. 5- Cytogenetic response can be detected in both groups and there is no difference between the two groups. Conclusion: 1.. Both Ph chromosome and bcr/abl fusion gene were important figures in diagnosis in CML and combining both is more evaluable; 2.. The change of Ph chromosome reflect the effect of treatment and its prognosis; 3.. Both groups can get cytogenetic response(PO.05).