Syndromes Of Renal Hypertension And Renal Pathological Damage And Other Related Factors

This thesis includes literature review and clinical studies.Renal parenehymal hypertension caused by a variety of renal diseases, is the most common secondary hypertension. Its incidence rate is about 5% to 10% with a rising trend in patients with secondary hypertension. Compared to primary hypertension, it can be more easily developed into malignant hypertension, and the cardiovascular lesion is more common. RPH is the independent risk factor that affects the prognosis of chronic renal disease. In recent years, primary hypertension is the focus of the integration study of western medicine and Chinese medicine. The TCM syndrome type standard of Hypertension was released according to experts'consensus. However, there is no any substantial TCM research and diagnosis Standard formulation on RPH yet, and there were no reports on the relevance of RPH TCM syndrome and renal pathology. Via on-site survey, the TCM syndrome and lab testing profile of RPH patients will be enrolled for the analysis of the relevance between the layout rules of TCM syndrome and renal pathology, renal function staging(stage),and hypertension classification. The study is aim to establish evidence-based TCM syndrome type which fit characteristics of renal hypertension disease, and to define the content of TCM syndrome type by covering the renal pathology, hypertension classification and CKD stage connotation. Thus it will help to improve the treatment efficacy of Chinese and western medicine integration.1 Literatures ReviewThe thesis reviewed literatures on some advantages and problems of the Chinese understanding of renal hypertension, experimental study, integrative Medicine treatment and relationship between TCM syndrome and renal pathology.2 Clinical ResearchAnalysis of the TCM Syndrome to 132 Patients with Renal Parenchymal Hypertension and their Renal Pathological Damage and Relevant FactorsAims:To provide theoretic basis for the diagnosis and treatment of renal parenehymal hypertension by the combination of Chinese and Western medicine through analyzing the relationship between the layout rules of TCM syndrome and renal pathology and the main prognostic factors.Methods:Via on-site survey, the TCM syndrome and lab testing profile of 132 renal parenehymal hypertension patients that have gone through biopsy have been enrolled for the analysis of the relevance between the layout rules of TCM syndrome and renal pathology, renal function staging(stage), and hypertension classification.Results:1 layout rules of TCM syndrome: more patients appeared deficiency syndrome, which divided into asthenia of both the spleen and kidney, kidney qi—yin asthenia, and yin insufficiency of liver kidney. Some patients belonged to sthenie syndrome which mainly includes internal retention of water, liver yang hyperactivity, and interior acctandation of dampness and turbid. Asthenia—sthenia syndrome complications were more common.2 Relationship between TCM syndrome and renal pathology:IgA nephropathy is often shown as liver kidney yin insufficiency and internal retention of water and liver yang hyperactivity. Membranous nephropathy is normally in the form of liver yang hyperactivity or kidney qi—yin asthenia. Fat related glomemlopathy is mainly in the expression of interior accumulation of dampness and turbid.3 Relationship between TCM syndrome and clarification of CKD:The clarification of chronic kidney disease(CKD)is closely related to three deficiency syndrome. Asthenia of both the spleen and kidney is closely related to CKDⅡ. Yin insufficiency of liver kidney is marked related to CKDⅠ-Ⅳ4 Relationship between TCM syndrome and hypertension grading:The third grade hypertension is often shown as liver kidney yin insuffideney. The second grade hypertension is normally in the form of liver yang hyperactivity. The first grade hypertension is mainly in the expression of internal retention of water and interior accumulation of dampness and turbid.Conclusion:Asthenia of both the spleen and kidney, kidney qi-yin asthenia, liver kidney yin insufficiency were three main categories of TCM syndrome. Different renal pathological damages, renal function and hypertension stage classification are to some extent related tO TCM Syndrome.