Acute Rabbit Ctni And Nt-probnp And Right Ventricular Pressure Change In Pulmonary Embolism And Right Ventricular Myocardial Injury And Significance

Objective:To study effects of different durations of thromboembolism on hemodynamics,blood gases,pulmonary arteriography and right ventricle myocardial pathology in a rabbit model with embolization of pulmonary lobar artery.Methods: twenty four rabbits were randomly divided into a control group,a mild pulmonary thromboembolism(PE)model group ,a severe PE model group with 8 rabbits each. PE was induced by infusing autologous blood clots(right jugular vein). Arterial blood gas were analyzed and the plasma's concentrations of cTnI and NT-proBNP were examined by ELISA before and 1h,2h,4h,8h after injection ,the hemodynamic monitoring were used by homemade catheter with multi-channel physiological recorder. The pathological changes of the lung and right ventricle myocardium were examined with light microscope at12h after injection.Results:â‘ h emodynamic monitoring showed that RV systolic pressures (RVSP) increased and MAP declined significantly in the severe PE model group, then gradually return close to normal after 4h. There were obviously differences between the severe PE model group and control group(P<0.01) and there were no differences between the mild PE model group and control group(P>0.05).â‘¡ELISA showed that NT-proBNP in the severe PE model group increased at 2h ,peaked at 8h ,which were higher than those in the control group and mild PE model group(P<0.01).cTnI in severe PE model increased at 4h,peak at 8h ,which were negative in control group and mild PE group.â‘¢Histopathological study showed that injury of right ventricle myocardium and lung injury were obvious in severe PE model group with inflammatory cell,also show there were vacuolar degeneration of right ventricle myocardiu in severe PE model group, but was less in mild PE model group.Conclusions:The change of cTnI,NT-proBNP and hemodynamic prove the truth that severe PE results right ventricle dysfunction. We can use cTnI,NT-proBNP as facilitate triage of PE, and we should pay attention to injury of right ventricle myocardium and RV dysfunction in clinic.