| Objective:To explore and study the effect of liver function on Child B-class Hepatocellular carcinoma with cirrhosis cases of surgical resection through ischemic and hormone preconditioning. Methods:Analysis of 90 cases of liver function as Child B-class Hepatocellular carcinoma with cirrhosis cases of surgical resection during July 1, 2005 to December 30,2007 in hepatic surgery deparment of our Hospital.90 patients were divided into three groups randomly and each group had 30 individuals. Such as ischemic preconditioning add Methylprednisolone Long group(group A),ischemic preconditioning group(group B) and control group without preconditioning(group C). Patients in every group before operation, end of operation, and after 1th,2 th,3 th,7 th,14th,21th day after the detection of liver function transit aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), total protein (TPRO), albumin (ALB), globulin (GLOB) targets. Results:1) Before surgery three group patients compared with the liver function was not significant (P> 0.05).2) End of operation and lth,2 th,3 th,7 th,14th,21th day after operation detection of TBIL. DBIL. IBIL. AST and ALT of group A and group B were both significantly lower than those of group C(P<0.05).3) End of operation and lth,2 th,3 th,7 th,14th,21th day after the detection of TBIL. DBIL. IBIL. AST and ALT of group A was significantly lower than those of group B(P<0.05).4)The TPRO,ALB.GLOB before and after operation compared between the three groups (P> 0.05), without statistical significance.Conclusions:The results show that both ischemic preconditioning add Methylprednisolone Long and simple ischemic preconditioning may have a protective effect against ischemia/reperfusion injury. Ischemic preconditioning add Methylprednisolone Long can reduce the liver function damage more significantly than simple ischemic preconditioning. |
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