The Synthesis And Application Of Betti Base

Chiral aminoalcohols(phenols) have been proved to be a very efficient class of ligands in a variety of catalytic asymmetric syntheses and chiral auxiliary syntheses catalyzed by metallic ions. Most of them were derived from a few readily available natural products. To increase understanding of asymmetric synthesis, design and synthesis of chiral ligands from non-natural resource is essential. Therefore, chiral aminoalcohols(phenols) are gaining progressive importance.The thesis here described the chiral resolution of Betti Base and the synthesis of their derivatives, as well as their potential applications.In the chapter one,that was reviewed of the Betti base and their derivatives's preparation .resolution and application.In the chapter two, an efficient resolution procedure was developed, which confirmed that the resolution of Betti base carried out in acetone follows a kinetic resolution mechanism and gave the resolution results in up to 81%yield and 99%ee.In the chapter three, the derivatives of Betti base were synthesized and examined as a resolution angents for etodolac.In the chapter four,β-iminocarboxylic esters 1 was prepared fromβ-ketocarboxylic esters and Betti base. The product was analysized by X-ray single crystal diffraction which shows that 1 is an inner salt. The physical and chemical property of 1 was also studied.1...